Melamine

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

other: human experience

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Only a short English abstract and an article in Polish are available. Workers were exposed at least to 2 substances, melamine and dicyandiamide (461-58-5), not enabling a statement on melamine.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1977

Materials and methods

Type of sensitisation studied:

skin

Study type:

survey

Principles of method if other than guideline:

The workers of the Division of Melamine and Dicyandiamide of the Nitrogen Works were examined. In all cases patch tests were carried out by the method of Jadassohn-Bloch with 1 % melamine and dicyandiamide. In subjects with skin changes patch tests were done additionally.

Test material

Test material information

Constituent 1

Reference substance name:

Melamine

EC Number:

203-615-4

EC Name:

Melamine

Cas Number:

108-78-1

Molecular formula:

C3H6N6

IUPAC Name:

1,3,5-triazine-2,4,6-triamine

Method

Type of population:

occupational

Applicant's summary and conclusion

Executive summary:

During these investigations 2 types of skin changes were observed. One showed typical morphological features and course of allergic contact dermatitis. These changes were caused by melamine and dicyandiamide as evidenced by positive results of patch tests.

Besides that, erythema of different intensity was observed on the skin exposed to sunlight. History data indicated that the factor causing their development was alcohol ingestion. The development of erythema was connected with the action of lime nitrogen and its aetiology was probably toxic.