Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-662-2 | CAS number: 67-64-1
Immunotoxicity
Administrative data
Description of key information
Antibody, plaque-forming cell assay (AFC): male CD-1 mice, 28 d by drinking water: NOAEL 1144 mg/kg bw/d
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 144 mg/kg bw/day
Additional information
The NOAEL for the assessment of immunotoxicity by the antibody, plaque-forming cell assay (AFC) in male CD-1 mice exposed to acetone in drinking water for 28 days was 1144 mg/kg bw/d. There was no effect on haematological parameters and thymus weights as further indicators of potential adverse effects on the immune system (Woolhiser et al., 2006).
Justification for classification or non-classification
No classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
