Registration Dossier
Registration Dossier
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EC number: 202-996-4 | CAS number: 102-01-2
Endpoint summary
Administrative data
Description of key information
LD50 values:
acute orla toxicity rat (KEY_401_1975_Lonza_ 1975-11-25) female: 5400, male: 6500 mg/kg bw
acute orla toxicity rat (NONKEY_401_1965_Hoechst_1965-11-30) female: 2450 mg/kg bw
acute orla toxicity cat (NONKEY_MetHb_1978_Hoechst_487/78) female: >100 mg/kg bw
acute orla toxicity cat (NONKEY_MetHb_1965_Hoechst_1965-11-30) male: >100, <=500 mg/kg bw
Key value for chemical safety assessment
Additional information
LD50 values of studies refering to acute toxicity are between 2450 and 6500 mg/kg bw for the rat and >100 and <=500 mg/kg bw for the cat. Data of these studies support conclusion that lethality is predominantly caused by methemoglobin (Met-Hb) formation. With respect to Met-Hb forming substances rats are known to react with lower sensitivity and cats with higher sensitivity than humans. Based on that the human acute toxicity dose is estimated to be higher than 300 but not higher than 2000 mg/kg bw.
Justification for classification or non-classification
LD50 estimates of >300 and <=2000 mg/kg bw for oral ingestion meet criteria for classification according to DIRCTIVE 67/548/EEC (2.2 DSD-DPD) or REGULATION (EC) No 1272/2008 (2.1 GHS / CLP). Since Met-Hb formation in humans is suspected and since systemic availability for all three exposure routs is not unlikely a precautionary classification as R20/21/22 or Cat 4, H302/H312/H332 irrespective of the routes tested is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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