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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation, other
Type of information:
other: risk assessment report
Adequacy of study:
weight of evidence
Study period:
May 2008
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature: European Union Risk Assessment Report Diphenylamine
Justification for type of information:
European Union Risk Assessment Report DIPHENYLAMINE

Data source

Reference
Reference Type:
publication
Title:
Contact dermatitis due to benzisothiazolone in a works analytical team
Author:
Slovak, A.J.M.
Year:
1980
Bibliographic source:
Contact Dermatitis; 6: 187-190

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
There was an outbreak of dermatitis in a group of 16 men involved in the quality control and analysis of fine organic chemicals, including diphenylamine. Eleven of the workers (the remaining four people were tested with another substance) were patch tested with a concentration of 1% diphenylamine in methanol.
GLP compliance:
not specified
Type of study:
other: patch test

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenylamine
EC Number:
204-539-4
EC Name:
Diphenylamine
Cas Number:
122-39-4
Molecular formula:
C12H11N
IUPAC Name:
diphenylamine
Specific details on test material used for the study:
No information available.

In vivo test system

Test animals

Species:
other: human
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No information available.

Results and discussion

Positive control results:
No information available.

In vivo (non-LLNA)

Results
Key result
Remarks on result:
no indication of skin sensitisation
Remarks:
There was an outbreak of dermatitis in a group of 16 men involved in the quality control and analysis of fine organic chemicals, including diphenylamine. Eleven of the workers (the remaining four people were tested with another substance) were patch tested with a concentration of 1% diphenylamine in methanol. None of the workers showed a positive response.

Any other information on results incl. tables

No detailed results are given in this report

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
There was an outbreak of dermatitis in a group of 16 men involved in the quality control and analysis of fine organic chemicals, including diphenylamine. Eleven of the workers (the remaining four people were tested with another substance) were patch tested with a concentration of 1% diphenylamine in methanol. None of the workers showed a positive response.