Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-539-4 | CAS number: 122-39-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: risk assessment report
- Adequacy of study:
- weight of evidence
- Study period:
- may 2008
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary litterature: European Union Risk Assessment Report DIPHENYLAMINE
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diphenylamine
- EC Number:
- 204-539-4
- EC Name:
- Diphenylamine
- Cas Number:
- 122-39-4
- Molecular formula:
- C12H11N
- IUPAC Name:
- diphenylamine
Constituent 1
Results and discussion
In vivo
Results
- Reversibility:
- no data
- Remarks on result:
- other: no signs of irritation observed within a 7 days observation period
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Diphenylamine caused no or only very slight skin irritation in tests with rabbits: Skin irritation potential of diphenylamine (no data on purity) was tested in the inner surface of the ears of two Albino rabbits by means of occlusive application of the substance for 24 hours (no information whether a vehicle was used or not used). There were no signs of irritation observed within a 7 days observation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
