Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-793-9 | CAS number: 151-56-4
Endpoint summary
Administrative data
Description of key information
The acute oral and acute dermal toxicity was investigated in studies performed comparable to the relevant guidelines (OECD420 and Hill, Ass. Food and Drug Off. 18, 1954), resulting in an LD50 of 4.9 mg/kg bw, and 12.45 mg/kg bw, respectively (BASF AG, 1967; BASF AG, 1965). The acute inhalation toxicity was investigated in a study according to internal BASF guidelines, an LC50 was not determined in this study (BASF AG, 1966).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4.9 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 12.45 mg/kg bw
Additional information
There are no human data on acute toxicity of ethyleneimine available.
The acute toxicity of ethyleneimine in animals is high. The available BASF studies on acute oral, inhalation and dermal toxicity were selected as the key studies as they were performed using methods comparable to relevant guidelines.
The oral LD50 was 4.9 mg/kg bw in rats in a well conducted study (BASF AG, 1967).
In a whole body inhalation study performed with rats the LC50 was not determined. 1 of 5 rats died 6 days after exposure to the test substance vapour (BASF AG, 1966).
The dermal LD50 was 12.45 mg/kg bw in rats in a well conducted study (BASF AG, 1965).
Justification for classification or non-classification
According to Annex I of Directive 67/548/EEC, the substance is classified as T+; R26/27/28.
According to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, the classification is H300, Cat. 2, H310, Cat. 2 and H330, Cat. 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
