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EC number: 201-116-6 | CAS number: 78-42-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Remarks:
- Type of genotoxicity: other: Mikronuclei
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
- Principles of method if other than guideline:
- other; Micronucleus assay
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 5 d
- Frequency of treatment:
- injection once daily on 3 consecutive days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
other: intraperitoneal injection of 0, 500, 1000, 2000 mg/kg test substance
- No. of animals per sex per dose:
- 5-6
- Control animals:
- yes
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
Any other information on results incl. tables
Tris(2 -Ethylhexyl)Phosphate
Overall result: Negative
The initial test gave a positive trend to 2,000 mg/kg with 1.1 MN-PCE/1,000 PCE in the control and 3.9 MN-PCE/1,000 PCE in the high dose group. Two repeat studies, one
to 2,000 mg/kg and one to 3,000 nng/kg were not positive by trend analysis and no dose groups were significantly elevated. Based on the lack of reproducibility of the effect seen in the initial test, this chemical is considered negative.
Initial Test:
Chemicala) | Tissueb) | Trendc) p value | Dosed) (mg/kg) | MN-PCE/1000e) (No.animals) | Pair-wisef) | Survivalg) | %PCEh) |
Tris(2 -ethylhexyl)phosphate (C) | BM | <0.001 | 0 | 1.10 +/-0.40(5) | 5/5 | 49.9 | |
Negative -/- | 500 | 1.90 +/-0.10(5) | 0.0719 | 5/5 | 46.4 | ||
1000 | 3.20 +/- 0.82 (5) | <0.001 | 5/5 | 54.7 | |||
2000 | 3.90 +/- 0.62(5) | <0.001 | 6/6 | 46.7 |
a) Chemical name
b) Tissue used (BM=bone marrow)
c) Value of P for trend analysis alpha= .05
d) chemical concentration administered i.p. daily to each animal
e) Micronucleated PCEs per 1000 PCE scored (+/- Standard Error of the Means) (Number of the Animals Scored).
f) The value of P fpr pair-wise comparisons between each treatment group and the concurrent solvent group alpha= .05.
g) No. of animals surviving treatment over number of animals treated
h) Percentage of erythrocytes that were polychromatic
Applicant's summary and conclusion
- Executive summary:
In an mouse bone marrow micronucleus assay the test substance was tested with following doses administered intraperitoneally to mice: 0, 500, 1000, 2000 mg/kg bw. The result was negative.
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