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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline study or GLP; limitations (No. of animals, course of experiment unclear, control substance not defined) .

Data source

Reference
Reference Type:
other: Microfiche
Title:
Unnamed
Year:
1990

Materials and methods

Principles of method if other than guideline:
other: no data concerning method
GLP compliance:
not specified
Type of study:
other: Drop on test
Justification for non-LLNA method:
The study pre-dates LLNA mathodology becoming validated by ECVAM and published as an OECD Guideline.

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-ethylhexyl) phosphate
EC Number:
201-116-6
EC Name:
Tris(2-ethylhexyl) phosphate
Cas Number:
78-42-2
Molecular formula:
C24H51O4P
IUPAC Name:
tris(2-ethylhexyl) phosphate
Details on test material:
no data

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other: See 'other information on results inc. tables' for details of experimental readings
Group:
test chemical
Total no. in group:
5
Remarks on result:
no indication of skin sensitisation
Remarks:
See 'any other information on results inc. tables'
Reading:
other: See 'other information on results inc. tables' for details of experimental readings
Group:
positive control
Dose level:
Phenylhydrasine control
Total no. in group:
5
Remarks on result:
positive indication of skin sensitisation
Remarks:
See 'any other information on results inc. tables'
Reading:
other: See 'other information on results inc. tables' for details of experimental readings
Group:
negative control
Dose level:
solvent control
Total no. in group:
5
Remarks on result:
no indication of skin sensitisation
Remarks:
See 'other information on results inc. tables'

Any other information on results incl. tables

Results:

 Solution   No.of animals (Guinea Pig)  Type of Test     Initial score     Final score
Skin sensitizytion    24 hrs  48 hrs  24 hrs  48 hrs
  Test substance Intramuscularly in A:D:CO  5  Drop on  1.0  0.6  1.0  0.9
 Phenylhydrasine control  5  Drop on  1.0  1.4  3.4  2.3
   Solvent control  5   Drop on  1.0  0.8  1.2  0.6

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test substance was found to be not sensitizing in this test system.
Executive summary:

In an old and very limited study not performed according actual guideline methods (Drop on test) the compound was tested in 5 guinea pigs (no further details about the method given). Solvent control (compound not specified) and positive control (Phenylhydrasine) was applied. The test substance, the solvent control and the positive control was evaluated with an initial score after 24 hours and after 48 hours. Also a final score was evaluated after 24 and 48 hours. The test substance was found to be not sensitizing in this test system.