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EC number: 201-116-6 | CAS number: 78-42-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Studies on Tri-(2-Ethylhexyl)-Phosphate
- Author:
- MacFarland H.N.; Punte C.L.
- Year:
- 1 966
- Bibliographic source:
- Archives of Environmental Health Vol. 13, pp.13-20
Materials and methods
- Principles of method if other than guideline:
- other: repeated dose dermal study in rabbits
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Details on test material:
- Mol wt: 434.6;
Sp g: 0.925 at 20 C;
n25D: 1.4473;
Surface tension: 31 dynes/sq cm;
Viscosity: 10.2 cp;
Vap press: 2 mm Hg at 200 C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Route of Administration: dermal
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 to 4 weeks
- Frequency of treatment:
- 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 ml/animal
Basis:
- No. of animals per sex per dose:
- 4 animals (2 weeks)
2 animals (4 weeks) - Control animals:
- not specified
- Details on study design:
- Post-exposure period: 3 - 17 d
Examinations
- Observations and examinations performed and frequency:
- see: any other information on materials and methods.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- effects observed, treatment-related
Effect levels
- Basis for effect level:
- other: see 'Remark'
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
animals appeared normal and gained weight, no alterations
were observed at necropsy. Skin: moderate erythema
following the first application, following subsequent
applications, the erythema did not increase in intensity,
but a gradual increase in the size of the affected zone was
observed. After the fifths application desquamination,
hemorrhagic areas, thickening of the skin. Microscopic
examination: hyperkeratosis, parakeratosis, good recovery.
Applicant's summary and conclusion
- Executive summary:
In an old and limited documented repeated dermal application study in rabbits the test substance was applied to the closely clipped, intact skin of the upper back of each of six male rabbits, at a daily dose of 0.1 ml. Applications were made on a five-day per week basis; four of the animals received a total of ten applications and the remaining two received 20 applications. The animals were observed for toxic effects and signs of dermal irritation daily. Initial, weekly, and terminal body weights were recorded. Two rabbits were sacrificed three days following the tenth application; two were sacrificed 17 days after the tenth application, and the remaining two on the third day after the 20th application. The animals appeared normal and gained weight; no alterations were observed at necropsy. In the skin moderate erythema following the first application, following subsequent applications was observed. The erythema did not increase in intensity, but a gradual increase in the size of the affected zone was observed. After the fifths application desquamination, hemorrhagic areas, thickening of the skin was seen. Microscopic examination revealed hyperkeratosis and parakeratosis. A Good recovery was evident in animals in which applications were stopped 17 days prior to sacrifice.
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