Registration Dossier
Registration Dossier
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EC number: 203-696-6 | CAS number: 109-69-3
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity: short-term oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only short abstract; insufficient for assessment to few data available
Data source
Reference
- Reference Type:
- publication
- Title:
- Hygienische Begründung für den zulässigen Gehalt Benzylchlorids und Butylchlorids in den Gewässern
- Author:
- Rudnev, M. I. et al.
- Year:
- 1 979
- Bibliographic source:
- Gig. Sanit. 3, 11-15
Materials and methods
- Principles of method if other than guideline:
- Immunotoxicity was evaluated in albino rats.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1-chlorobutane
- EC Number:
- 203-696-6
- EC Name:
- 1-chlorobutane
- Cas Number:
- 109-69-3
- Molecular formula:
- C4H9Cl
- IUPAC Name:
- 1-chlorobutane
- Details on test material:
- - Name of test material (as cited in study report): Chlorbutyl
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 days
- Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.00022, 0.0022, 0.022 and 110 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Details on results:
Any other information on results incl. tables
The authors interpreted the results as indication of possible dose dependent sensitization reactions. Since the criteria of the assessment are not documented, the study is difficult to evaluate.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
