Registration Dossier
Registration Dossier
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EC number: 203-696-6 | CAS number: 109-69-3
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: too few data for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on Chemical Carcinogens. XXIII. A Simple Method for Characterization of the Alkylating Ability of Compounds by using 4-(p-Nitrobenzyl)pyridine
- Author:
- Kawazoe, Y. et al.
- Year:
- 1 982
- Bibliographic source:
- Chem. Pharm. Bull. 30, 2077-2086
Materials and methods
- Type of study / information:
- alkylating potency
- Principles of method if other than guideline:
- Alkylating agents were characterized by measuring the reaction selectivity towards 4-(p-nitrobenzyl)pyridine (NBP) in acetone containing phosphate buffer.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chlorobutane
- EC Number:
- 203-696-6
- EC Name:
- 1-chlorobutane
- Cas Number:
- 109-69-3
- Molecular formula:
- C4H9Cl
- IUPAC Name:
- 1-chlorobutane
Constituent 1
Results and discussion
Any other information on results incl. tables
In this solution n-butyl chloride had a half life of 90 hours and a selectivity constant of 1.52, demonstrating a low reactivity under the reaction conditions.
Applicant's summary and conclusion
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