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Diss Factsheets
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EC number: 271-802-8 | CAS number: 68608-82-2 A complex combination of hydrocarbons obtained by the alkylation of benzene with ethene. It consists primarily of ethylbiphenyls, diethylbenzenes with lesser amounts of butylbenzenes and polyethylbenzenes.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report does not mention whether GLP was followed, but sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures).
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- other: vapor from liquid
- Details on test material:
- - Name of test material (as cited in study report): 1,1 diphenylethane
- Physical state: Clear, colorless liquid
- Lot/batch No.: 31525
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Supplier- Charles River Breeding Laboratories, Inc., Wilmington, Mass.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- other: No data but whole body exposure was typically conducted.
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures).
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 1.6 and 1.5 mg/L
- No. of animals per sex per dose:
- 4 male rats/exposure
- Control animals:
- no
- Details on study design:
- Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures). Observations and body weight were recorded and a gross pathological examination was conducted 2 weeks post-treatment.
- Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 1.6 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: Two 1-hour exposures
- Mortality:
- None
- Clinical signs:
- other: Slight, transient eye irritation. At the end of the exposure period the rats were somewhat excitable. However, all rats appeared healthy and gained weight during the 2-week observation period.
- Body weight:
- All rats appeared healthy and gained weight during the 2-week observation period.
- Gross pathology:
- No lesions attributable to exposure to the test material were observed upon gross pathological examination 2 weeks after exposure.
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature resulted in slight, transient eye irritation. There were no mortalities of test animals. No lesions attributable to exposure to the test material were observed upon gross pathological examination 2 weeks after exposure.
- Executive summary:
Two 1-hour exposures of 4 male rats/exposure to vapor of the 1,1-diphenylethane test material (reference 31525 and a clear, colorless liquid) generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures) resulted in slight, transient eye irritation. At the end of the exposure period the rats were somewhat excitable. However, all rats appeared healthy and gained weight during the 2-week observation period. No lesions attributable to exposure to the test material were observed upon gross pathological examination 2 weeks after exposure. The LC50 for 1,1-diphenylethane was > 1.6 mg/L air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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