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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to
Guideline:
other: JIS K 0102-1986, 71
Principles of method if other than guideline:
conducted in accordance with "Method for Testing the Bioaccumulation of new chemical substances in Fish" (Kanpogyo No .S, Yakuhatsu No . 615, 49-Kikyoku No . 392, MITI/MHW Chemical Substance Control Law, Japan, promulgated July 13, 1974).
GLP compliance:
no
Vehicle:
no
Test organisms (species):
Cyprinus carpio
Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
8 wk
Test temperature:
25 °C
Details on test conditions:
TEST SYSTEM
- Renewal rate of test solution (flow rate): 580 L per day
- No. of organisms per vessel: 20
Nominal and measured concentrations:
Nominal test concentration: 0.1 and 0.01 mg/L

Type:
BCF
Value:
47 - 55
Time of plateau:
8 wk
Remarks on result:
other: after 2 weeks
Remarks:
Conc.in environment / dose:0.1
Type:
BCF
Value:
38 - 55
Time of plateau:
8 wk
Remarks on result:
other: after 4 weeks
Remarks:
Conc.in environment / dose:0.1
Type:
BCF
Value:
37 - 42
Time of plateau:
8 wk
Remarks on result:
other: after 6 weeks
Remarks:
Conc.in environment / dose:0.1
Type:
BCF
Value:
23 - 40
Time of plateau:
8 wk
Remarks on result:
other: after 8 weeks
Remarks:
Conc.in environment / dose:0.1
Type:
BCF
Value:
53 - 72
Time of plateau:
8 wk
Remarks on result:
other: after 2 weeks
Remarks:
Conc.in environment / dose:0.01
Type:
BCF
Value:
22 - 32
Time of plateau:
8 wk
Remarks on result:
other: after 4 weeks
Remarks:
Conc.in environment / dose:0.01
Type:
BCF
Value:
31 - 56
Time of plateau:
8 wk
Remarks on result:
other: after 6 weeks
Remarks:
Conc.in environment / dose:0.01
Type:
BCF
Value:
18 - 22
Time of plateau:
8 wk
Remarks on result:
other: after 8 weeks
Remarks:
Conc.in environment / dose:0.01

Actual means of test concentration in test solution (mg/l )

nominal 0.1: 0.0864 (2 wk), 0.0917 (4 wk), 0.0946 (6 wk), 0.0952 (8 wk)

nominal 0.01: 0.00827 (2 wk), 0.00895 (4 wk), 0.00926 (6 wk), 0.00936 (8 wk)

Description of key information

Key value for chemical safety assessment

BCF (aquatic species):
72 dimensionless

Additional information

A bioaccumulation study with Cyprinus carpio has been performed according to the Japanese guideline “Method for Testing the Bioaccumulation of new chemical substances in Fish”. Organisms have been exposed for 8 weeks in a flow-through system to substance concentrations of 0.1 mg/l and 0.01 mg/l. The BCF was 23-55 for the higher concentration (0.1 mg/l) and 18-72 for the lower concentration (0.01 mg/l), respectively. The analytical measurements were performed after 2, 4, 6 and 8 weeks.