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Diss Factsheets
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EC number: 701-269-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
- Endpoint:
- biodegradation in soil: simulation testing
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- Testing for the biodegradation in soil endpoint is waived for the test substance EW-84. Feasibility of laboratory testing has been technically challenging due to the very poor water solubility (0.115 mg/l) of the test and read-across substances. The substance is inherently biodegradable in water (van Ginkel, 2013) based on a GLP compliant OECD Guideline 301D study using the read-across substance octadecanoic acid, 12-hydroxy-, reaction products with ethylenediamine (CAS 100545-48-0). The test substance biodegraded by 22% at day 28 and 37% at day 60 (during the prolonged closed bottle test). Furthermore, a study conducted to increase the availability indicated that the poor water solubility led to slow desorption and dissolution rates of the test substance at high concentrations and was responsible for affecting the biodegradation kinetics. In addition, the study was conducted in river water, which was likely to have had a lower microbial activity than the more usual activated sludge inoculum leading to slower degradation rate. As the test substance is expected to be present in the environment at concentrations in the range of μg/L or lower, faster and more complete degradation may be anticipated under these conditions within a shorter time period (van Ginkel, 2013).
Laboratory studies using the test substance on terrestrial organisms have recently been completed. These include the soil microorganisms nitrogen transformation (OECD 216), earthworm reproduction (OECD 222) and long-term toxicity to terrestrial plants, 6 species (OECD 208). No or low toxicity was reported in these studies with a low potential risk to the terrestrial environment predicted. As confirmed previously, the aquatic toxicity testing carried out to date indicated that the substance is not toxic at the level of solubility.
Further testing on soil biodegradation is waived on the basis of technical feasibility of a study with a very poorly soluble substance and a substance that has not demonstrated toxicity to aquatic and terestrial organisms at its level of solubility. In addition, the results of the aquatic biodegradation test indicated that the substance is inherently biodegradable with the likelihood that degradation would be faster and more complete under sewage treatment work and environmental conditions.
Data source
Materials and methods
Test material
- Reference substance name:
- Reaction mass of N,N’-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide), Octadecanamide, 12-hydroxy-N-[2-[(1-oxooctadecyl)amino]ethyl]- and Octadecanoic acid, 12-hydroxy-, 1-hexyl-12-[[2-[(12-hydroxy-1-oxooctadecyl)amino]ethyl]amino]-12-oxododecyl ester
- EC Number:
- 701-269-3
- Molecular formula:
- C38H76N2O4
- IUPAC Name:
- Reaction mass of N,N’-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide), Octadecanamide, 12-hydroxy-N-[2-[(1-oxooctadecyl)amino]ethyl]- and Octadecanoic acid, 12-hydroxy-, 1-hexyl-12-[[2-[(12-hydroxy-1-oxooctadecyl)amino]ethyl]amino]-12-oxododecyl ester
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.