Registration Dossier
Registration Dossier
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EC number: 701-269-3 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96 h LL50 of the read-across substance bisamide (UVCB) to rainbow trout was >10 mg/L (nominal loading rate). The nominal “no observed effect loading rate” (NOELR) was 10 mg/L. No toxicity was observed at the limit of solubility.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 10 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 10 mg/L
Additional information
A study was performed to assess the acute toxicity of the read-across substance bisamide (UVCB) to rainbow trout (Oncorhynchus mykiss) under semi-static conditions according to EU Method C.1 and OECD Guideline 203 in compliance with GLP. A group of ten juvenile fish was exposed to a water accommodated fraction (WAF) prepared from an aqueous mixture with an initial nominal loading rate of 10 mg/l (direct addition of the test substance to the diluent water). To aid dissolution, the aqueous mixture was stirred for approximately 24 h in the dark and then left to stand for another 24 h in the dark before the aqueous phase was removed and filtered (0.2 μm pore size cellulose nitrate). The resultant WAF was used in the test. Concentrations were not verified analytically because of the high insolubility of the substance; results were therefore expressed as nominal loading rates. Observations of the fish were made after approximately 2, 4, 24, 48, 72 and 96 h of exposure. No mortality or treatment-related toxicity effects were seen in either the control or at the nominal loading rate of 10 mg/l. Under the study conditions, the 96 h LL50 of the test substance to rainbow trout was > 10 mg/l (nominal loading rate). The nominal no observed effect loading rate (NOELR) was 10 mg/l. No toxicity was observed at the limit of solubility.
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