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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Dose doc. no. : P108
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE);Chemical Safety Data Sheets 1992, 4b, 130-131, The Royal Society of Chemistry, London, UK.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from Dose database
GLP compliance:
not specified
Type of study:
not specified

Test material

Constituent 1
Reference substance name:
Phenylhydrazine
EC Number:
202-873-5
EC Name:
Phenylhydrazine
Cas Number:
100-63-0
IUPAC Name:
phenylhydrazine
Details on test material:
- Name of test material : Phenylhydrazine

In vivo test system

Test animals

Species:
human
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: unspecified
Vehicle:
no data

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Clinical observations:
Causes skin sensitisation in humans
Remarks on result:
other: Reading: 1st reading. Group: test group. Clinical observations: Causes skin sensitisation in humans .

Any other information on results incl. tables

Causes skin sensitisation in humans

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Phenyl hydrazine Causes skin sensitisation in humans.
Executive summary:

Phenyl hydrazine Causes skin sensitisation in humans. Moreover it is a known fact that hydrazine group is carcinogenic in nature and so based on all the weight of evidence effect it can be concluded that the target substance, Benzylhydrazine dihydrochloride, will have skin sensitising effect on human skin as well (as this read across analog is 80% structurally similar to the target chemical).