Registration Dossier
Registration Dossier
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EC number: 243-887-1 | CAS number: 20570-96-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Dose doc. no. : P108
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE);Chemical Safety Data Sheets 1992, 4b, 130-131, The Royal Society of Chemistry, London, UK.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from Dose database
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Phenylhydrazine
- EC Number:
- 202-873-5
- EC Name:
- Phenylhydrazine
- Cas Number:
- 100-63-0
- IUPAC Name:
- phenylhydrazine
- Details on test material:
- - Name of test material : Phenylhydrazine
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: unspecified
- Vehicle:
- no data
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- Causes skin sensitisation in humans
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: Causes skin sensitisation in humans .
Any other information on results incl. tables
Causes skin sensitisation in humans
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Phenyl hydrazine Causes skin sensitisation in humans.
- Executive summary:
Phenyl hydrazine Causes skin sensitisation in humans. Moreover it is a known fact that hydrazine group is carcinogenic in nature and so based on all the weight of evidence effect it can be concluded that the target substance, Benzylhydrazine dihydrochloride, will have skin sensitising effect on human skin as well (as this read across analog is 80% structurally similar to the target chemical).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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