Registration Dossier
Registration Dossier
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EC number: 243-887-1 | CAS number: 20570-96-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted Data
- Title:
- 27.12.2012 17:54 [R]: 230 mg/L "Ecotoxicological Information#Aquatic Toxicity" for 20570-96-1
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox Version 3.0
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is predicted by QSAR toolbox version 3.0
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzylhydrazine dihydrochloride
- EC Number:
- 243-887-1
- EC Name:
- Benzylhydrazine dihydrochloride
- Cas Number:
- 20570-96-1
- Molecular formula:
- C7H10N2.2ClH
- IUPAC Name:
- benzylhydrazine dihydrochloride
- Details on test material:
- Substance name - Benzylhydrazine dihydrochloride
Substance type : organic
Molecular Formula: C7H10N2
SMILES:c1(CNN)ccccc1_Cl_Cl
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 230.442 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: Growth
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: EC50
Estimation method: Takes lowest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a" and "b" ) and "c" ) and ("d" and "e" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(CNN)ccccc1_Cl_Cl
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Reactive unspecified by Acute aquatic toxicity MOA by OASIS
Domain logical expression index: "c"
Similarity boundary:Target: c1(CNN)ccccc1_Cl_Cl
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.145
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.08
Applicant's summary and conclusion
- Conclusions:
- The effective concentration (EC50) value of Benzylhydrazine dihydrochloridein algae Pseudokirchneriella subcapitata in a 72 hr study on growth effect was estimated to be 230.44 mg/L.
- Executive summary:
The effective concentration (EC50) value of Benzylhydrazine dihydrochloridein algae Pseudokirchneriella subcapitata in a 72 hr study on growth effect was estimated to be 230.44 mg/L. Thus considering CLP Criteria for aquatic classification of the substance , it is concluded that Benzylhydrazine dihydrochloride shall not exhibit short term toxicity to green algae Pseudokirchneriella subcapitata
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