Registration Dossier
Registration Dossier
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EC number: 201-137-0 | CAS number: 78-73-9
Endpoint summary
Administrative data
Description of key information
Additional information
The potential for bioaccumulation in aquatic organisms (most likely in fish) was not determined experimentally for Choline hydrogen carbonate. It was not possible to determine the logPow experimentally and based on the substance composition, a bioaccumulation study can be waived in accordance to REACH, Annex IX, Section 9.3.2, column 2.
The Bioconcentration factor (BCF) is an important parameter for the chemical safety assessment (CSA) and is therefore mostly determined with scientifically accepted QSAR predictions. In the case for Choline hydrogen carbonate, however, such a prediction is not possible. The substance is lying out of the domain in the EPIWIN software BCFBAF v3.01. Therefore, the prediction result for the reliable read-across substance Choline chloride (CAS 67-48-1) is taken into account (Chemservice S.A., 2013). Using the regression-based estimate (traditional method) a BCF of 3.16 L/kg wet-wt was predicted. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 0.893 L/kg wet-wt is the result. These results confirm that bioaccumulation in aquatic organisms is unlikely for the read-across substance and the same can be considered for the target one. For details and justification of the read-across procedure, please refer to the separate read-across statement (Chemservice S.A., 2013).
Also terrestrial bioaccumulation of Choline hydrogen carbonate is not expected. However, no information is available and this endpoint is no mandatory requirement under REACH.
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