Registration Dossier
Registration Dossier
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EC number: 904-153-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
A 96 hour acute semi-static toxicity study in zebra fish (Brachydanio rerio) was performed to assess the toxicity of Polyol TD. The study was performed according to GLP and the OECD 203 Test Guideline. The 96 hour LC50 was calculated to be 1250 mg/L (based nominal exposure concentrations), the corresponding NOEC was 500 mg/L (nominal concentration) (Olsson, 2008).
A static 48 hour definitive test was performed exposing Daphnia magna to a range of concentrations (125 - 4000 mg/L) of Polyol TD. The study was performed in accordance with the OECD guideline 202 and according to GLP. The 48 hour EC50 was calculated to be 1090 mg/L (based on nominal concentrations), the corresponding no-observed effect concentration was observed to be 500 mg/L (nominal concentration) ( Sjölin, 2008).
A 72 hour algal growth inhibition study, test species Pseudokirchneriella subcaptitata, was performed to determine the toxic effects of the test substance Polyol TD. The test was conducted according to OECD test guideline 201, and performed to GLP. Based on nominal exposure concentrations the 72 hour ErC50 was calculated to be 743 mg/L and the corresponding no-observed effect concentration (NOEC) was 62 mg/L. The 72 hour EyC50 was calculated to be 144 mg/L and the corresponding NOEC was 62 mg/L ( Sjölin, 2008).
The chronic toxicity of Polyol TD was tested in a preliminary 21-days Daphnia magna repoduction test according to OECD test guideline 211. The study was performed as a limit test using a single test concentration of 62 mg/L based on data of acute toxicity studies as mentioned above. The study demonstrates that there is no statistically significant effect at the limit concentration.Thus, D. magna is not more sensitive to Polyol TD than Pseudokirchneriella subcaptitata.
The toxicity of Polyol TD to activated sewage sludge was investigated in a respiration inhibition test according to OECD test guideline 209. Following three hours exposure to Polyol TD the EC50 was observed to be > 1000 mg/L (based on nominal exposure concentrations), the corresponding NOEC was observed to 1000 mg/L (Knight, polyol TD, 2010).
Additional information
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