Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-10-11
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
GLP compliance:
no
Type of method:
distillation method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Substance type: mixture
- Physical state: liquid
- Lot/batch No.: 3577927
- Storage condition of test material: room temperature

- Composition of test material, percentage of components:
*5-ethyl-5hydroxymethyl-1,3-dioxane (CTF) 48.5 % (w/w) CAS 5187-23-5
*1,3-propanediol, 2-ethyl (DMP)19.2% (w/w) CAS 2612-29-5
*2-Ethyl-2-hydroxymethyl-1,3-propanediol (TMP) 15.1 % (w/w) CAS 77-99-6

Results and discussion

Boiling point
Boiling pt.:
506 K
Atm. press.:
101.3 kPa
Decomposition:
no
Remarks on result:
other: Mean value from two measurements

Any other information on results incl. tables

Value 1.

Volume

Temperature

1stdrop

230.4 ºC

1 ml

231.1 ºC

5 ml

231.5 ºC

10 ml

232.2 ºC

20 ml

234.0 ºC

30 ml

236.0 ºC

40 ml

238.0 ºC

50 ml

240.1 ºC

60 ml

243.5 ºC

70 ml

249.0 ºC

80 ml

275.6 ºC

90 ml

304.2 ºC

95 ml

314.0 ºC

Dry

314.8 ºC

Value 2.

Volume

Temperature

1stdrop

230.9 ºC

1 ml

231.5 ºC

5 ml

231.6 ºC

10 ml

232.5 ºC

20 ml

232.8 ºC

30 ml

234.4 ºC

40 ml

235.7 ºC

50 ml

236.0 ºC

60 ml

246.3 ºC

70 ml

251.1 ºC

80 ml

 

90 ml

 

95 ml

 

Dry

264.8 ºC

The measured temperatures were corrected to 101.3 kPa at 0°C, according to ISO 918-1983 and European Pharmacopoeia 6.0 (part 2.2.11).

Value 1, corrected:               505.5 K (232.3 °C) at 101.3 kPa

Value 2, corrected:               506.5 K (233.3 °C) at 101.3 kPa

Applicant's summary and conclusion

Conclusions:
Boiling Point: 506 K (233 °C) at 101.3 kPa
Executive summary:

Boiling point: 506 K (233 °C) at 101.3 kPa