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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to
Guideline:
other: Screening test is similar to the preliminary test in OECD guideline for the testing of chemicals, no. 105, water solubility
Principles of method if other than guideline:
The solubility of the test substance is investigated in a combined screening test (which is similar to OECD TG 105) followed by LCMS analysis of solutions obtained in the screening test.

Key result
Medium:
n-octanol
Solubility:
520 g/L
Temp.:
23 °C
Remarks on result:
other: analysed using LCMS
Details on results:
There were two fractions analysed, F1 and F2. The result from the F1 test was used as the result. Since there was no visible undissolved substance in F2 it was not certain that the F2 test was saturated. The carbon chain distribution in the F1 test differed from the standard. There was more of the shorter carbon chain components in the F1 test (41% compared to 33% in the standard), indicating that the longer carbon chain component was saturated.
Conclusions:
Under the study conditions, the octanol solubility of the test substance was determined to be 520 g/L at 23°C.
Executive summary:

A study was conducted to determine the octanol solubility of the test substance, C16-18 TMAC (72.78% active) using a combined screening test and LCMS analysis, according to a method equivalent to OECD Guideline 105. The measurement was performed at room temperature, approximately 23°C. Under the study conditions, the octanol solubility of the test substance was determined to be 520 g/L at 23°C (Famback, 2012).

Description of key information

The octanol solubility of the test substance was determined using a combined screening test and LCMS analysis, according to a method equivalent to OECD Guideline 105 (Farnback M, 2012).

Key value for chemical safety assessment

Additional information

(n-octanol solubility = 520g/L at 23°C)