Registration Dossier
Registration Dossier
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EC number: 209-264-3 | CAS number: 563-80-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In the key study, a non-guideline skin sensitization study conducted according to an internal Eastman Kodak Company method in which 10 guinea pigs were induced with injection of 1% methyl isopropyl ketone using the footpad technique and challenged 7 days later via dermal application, there was no increased incidence of erythema or edema when compared to the negative control.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
No evidence of a sensitization response was observed when groups of guinea pigs were immunized with methyl isopropyl ketone using the footpad technique and challenged seven days later via dermal application. Based on a weight-of-the-evidence assessment, methyl isopropyl ketone is not classified for “Skin Sensitization” according to GHS.
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