Registration Dossier
Registration Dossier
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EC number: 209-264-3 | CAS number: 563-80-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
OECD 209 Activated Sludge Respiration Inhibition Test from structural analog substance
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
In accordance with column 2 of REACH Annex VIII, the activated sludge respiration inhibition test does not need to be conducted as Methyl Isopropyl Ketone (MIPK) was found to be readily biodegradable and the applied test concentrations are in the range of concentrations that can be expected in the influent of a sewage treatment plant. However, for purposes of defining the key value for the chemical safety assessment, read across to the activated sludge respiration inhibition test results for the structural analog substance, Methyl Isoamyl Ketone (MIAK), is being performed. In addition to both substances being structurally similar, both substances underwent ready biodegradation studies using the same methodology, OECD 301D Closed Bottle Test, and both substances were found to be readily biodegradable. MIAK exhibited 67% degradation in the 28 day study and MIPK exhibited 85.1%. As MIAK exhibited less degradation it is believed that this the result from the MIAK activated sludge respiration inhibition test is conservative for read across to MIPK. The activated sludge respiration inhibition test of MIAK exhibited no inhibition to the microorganisms under the conditions of the test (NOEC = 1000 mg/L) which has been used to define the PNEC using an assessment factor of 10.
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