Registration Dossier
Registration Dossier
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EC number: 231-445-0 | CAS number: 7554-65-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Animal experimental study, published in peer reviewed literature.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of pyrazole and 4-methylpyrazole in mice and rats.
- Author:
- Magnusson G. et al
- Year:
- 1 972
- Bibliographic source:
- Experientia. 1972 Oct 15;28(10):1198-200.
Materials and methods
- Principles of method if other than guideline:
- Ten male NMRI mice per dose were exposed intravenously to the test substance diluted in physiological saline. Animals were observed for 7 days and mortalities were recorded.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylpyrazole
- EC Number:
- 231-445-0
- EC Name:
- 4-methylpyrazole
- Cas Number:
- 7554-65-6
- Molecular formula:
- C4H6N2
- IUPAC Name:
- 4-methyl-1H-pyrazole
- Details on test material:
- Name of test material (as cited in study article): 4-methylpyrazole
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 18 - 22 g
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- physiological saline
- Details on exposure:
- Administered as solution in 6 dose levels.
- No. of animals per sex per dose:
- 10 male animals
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 7 days
- Statistics:
- Values for LD50 were calculated from the recorded mortalities by the method of Litchfield and Wilcoxon (1949).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.8 other: mmol/kg bw
- Based on:
- test mat.
- 95% CL:
- 3.2 - 4.6
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 312 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
