Registration Dossier
Registration Dossier
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EC number: 231-445-0 | CAS number: 7554-65-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Animal experimental study, published in peer reviewed literature, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of pyrazole and 4-methylpyrazole in mice and rats.
- Author:
- Magnusson G. et al
- Year:
- 1 972
- Bibliographic source:
- Experientia. 1972 Oct 15;28(10):1198-200.
Materials and methods
- Principles of method if other than guideline:
- Six male Sprague-Dawley rats per dose were exposed orally to the test substance diluted in physiological saline. Animals were observed for 7 days and mortalities were recorded.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylpyrazole
- EC Number:
- 231-445-0
- EC Name:
- 4-methylpyrazole
- Cas Number:
- 7554-65-6
- Molecular formula:
- C4H6N2
- IUPAC Name:
- 4-methyl-1H-pyrazole
- Details on test material:
- Name of test material (as cited in study article): 4-methylpyrazole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 170 g (mean)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- physiological saline
- Details on oral exposure:
- Administered as solution in 6 dose levels.
- No. of animals per sex per dose:
- 6 male animals
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 7 days
- Statistics:
- Values for LD50 were calculated from the recorded mortalities by the method of Litchfield and Wilcoxon (1949).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6.5 other: mmol/kg bw
- Based on:
- test mat.
- 95% CL:
- 5.9 - 7.1
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 534 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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