5-amino-6-methyl-1,3-dihydrobenzoimidazol-2-one

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

other: not verifiable

Rationale for reliability incl. deficiencies:

other: no information given in SNIF-file

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

1998

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 92/69/EWG, B.3; OECD 402 (1987)

GLP compliance:

yes

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

670-36-2

IUPAC Name:

670-36-2

Constituent 2

Reference substance name:

-

EC Number:

428-410-9

EC Name:

-

Cas Number:

67014-36-2

Molecular formula:

C8H9N3O

IUPAC Name:

5-amino-6-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one

Test animals

Species:

other: rat, Wistar Crl:(WI)BR

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

propylene glycol

Duration of exposure:

24 h

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: No findings were observed.

Gross pathology:

Effects on organs: No findings were observed.

Other findings:

Signs of toxicity (local):
Red staining of the neck was noted in two females between days 7 and 12.
Brown staining of the treated skin-area was seen among the animals during the observation period and erythema was seen in the treated skin-area
of one male on day 2.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU