Registration Dossier
Registration Dossier
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EC number: 428-410-9 | CAS number: 67014-36-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- other: not verifiable
- Rationale for reliability incl. deficiencies:
- other: no information given in SNIF-file
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EG, B.1tris (Akute-toxische-Klassen-Methode); OECD 423 (1996)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 428-410-9
- EC Name:
- -
- Cas Number:
- 67014-36-2
- Molecular formula:
- C8H9N3O
- IUPAC Name:
- 5-amino-6-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one
Constituent 1
Test animals
- Species:
- other: rat, Wistar Crl:(WI)BR
Administration / exposure
- Vehicle:
- propylene glycol
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 2 000 mg/kg bw
- Mortality:
- Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 1 - Clinical signs:
- other: Clinical signs observed during the period were as follows, 2000 mg/kg: Lethargy, hunched posture, uncoordinated movements, piloerection, red staining of the nose, laboured respiration and emaciation was noted among the animals that died. Lethargy, hunched
- Gross pathology:
- Effects on organs:
Beginning of autolysis, enlarged kidneys and reduction in size of spleen, thymus and semial vesicales was found among the animals that died during the study.
No abnormalities were found at macroscopic post mortem examination of the surviving animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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