Registration Dossier
Registration Dossier
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EC number: 428-410-9 | CAS number: 67014-36-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: testing method performed according to OECD107
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- -
- EC Number:
- 428-410-9
- EC Name:
- -
- Cas Number:
- 67014-36-2
- Molecular formula:
- C8H9N3O
- IUPAC Name:
- 5-amino-6-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Any other information on results incl. tables
Results in detail: Stock solution: 734 mg/l
| determ. no. | stock solution [ml] | water [ml] | test substance conc. in n-octanol phase [mg/l] | test substance conc. in water phase [mg/l] | log Pow |
A1 |
5 | 10 | 254,0 | 153,5 | 0,22 |
| A2 | 5 | 10 | 269,1 | 154,5 | 0,24 |
| B1 | 10 | 10 | 411,5 | 259,7 | 0,20 |
| B2 | 10 | 10 | 462,2 | 264,6 | 0,24 |
| C1 | 20 | 10 | 685,4 | 379,8 | 0,26 |
| C2 | 20 | 10 | 599,5 | 385,5 | 0,19 |
| mean | --- | --- | --- | --- | 0,22 |
Applicant's summary and conclusion
- Conclusions:
- Due to the partition coefficient n-octanol-water of 0.22 at 23°C bioaccumulation is not expected.
- Executive summary:
The partition coefficient n-octanol/water was determined according to OECD 107. The result was LogPow=0.22 at 23°C.
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