Registration Dossier
Registration Dossier
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EC number: 231-104-6 | CAS number: 7439-95-4
Toxic effects on livestock and pets
Administrative data
Description of key information
Expert Judgement
Magnesium is an essential metal for human, animal and plant life. Judging from the litterature, the focus with respect to magnesium, is on the effects of Mg deficiencies rather than the toxic properties of the metal.
Normal serum magnesium concentrations range from 0.5-1.3 mmol/L, averaging 0.87-0.93 mmol/L, in adults of either sex. An average of 34% of total serum magnesium is bound to protein. Normal urine contains 1-6 mmol/L of magnesium.
In dogs, magnesium was quickly distributed throughout the body after administration, with the highest concentrations found in kidneys, liver, and heart. About 22% of a dose was eliminated in the urine within 3 hours, and 25% within 24 hours. Only about 1% was excreted in the faeces. Skeletal muscle and bone account for a large portion of body burden of magnesium.
Reference:
Baselt RC, Cravey RH, eds. Magnesium. In: Disposition of toxic drugs and chemicals in man. 3rd ed. Chicago, USA: Year Book Medical Publ, Inc, 1990: 437-74.
Due to the absence of chemical groups or other structural alerts this substance is not considered to exhibit an high hazard potential.
Therefore testing for Toxic effects on livestock and pets does not need to be performed.
Additional information
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