Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Salmonella Mutagenicity Tests: III. Results From the Testing of 255 Chemicals
Author:
Errol Zeiger, Beth Anderson, Steve Haworth, Timothy Lawlor, Kristien Mortelmans, William Speck
Year:
1987
Bibliographic source:
Environmental Mutagenesis Volume 9, Supplement 9: 1-110

Materials and methods

GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Test concentrations with justification for top dose:
0 - 10000 µg/plate
Vehicle / solvent:
H2O

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA98, TA100, TA1535, and TA1537
Metabolic activation:
not specified
Genotoxicity:
negative

Any other information on results incl. tables

One in vitro mutagenicity assay in S. typhimurium strains was negative for 2-aminopyridine.

Applicant's summary and conclusion