Registration Dossier
Registration Dossier
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EC number: 207-988-4 | CAS number: 504-29-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Health Council of the Netherlands: Committee on Updating of Occupational Exposure Limits. 2-Pyridylamine
- Year:
- 2 002
- Bibliographic source:
- Health Council of the Netherlands: Committee on Updating of Occupational Exposure Limits. 2-Pyridylamine
Materials and methods
Test guideline
- Guideline:
- other: not specified
- Principles of method if other than guideline:
- Method not known
- GLP compliance:
- not specified
- Remarks:
- bibliographic research data
Test material
- Reference substance name:
- 2-pyridylamine
- EC Number:
- 207-988-4
- EC Name:
- 2-pyridylamine
- Cas Number:
- 504-29-0
- Molecular formula:
- C5H6N2
- IUPAC Name:
- pyridin-2-amine
1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- water
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- other: not specified
- Time point:
- other: not specified
- Reversibility:
- fully reversible
- Remarks on result:
- positive indication of irritation
- Remarks:
- No further studies of ocular irritation are available
- Irritant / corrosive response data:
- Slight and temporary ocular lesion (opacity of the cornea).
- Other effects:
- No further studies of ocular irritation are available.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The substance is classified as Causes serious eye irritation (CLP Regulation - category 2)
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