Registration Dossier
Registration Dossier
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EC number: 207-988-4 | CAS number: 504-29-0
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Cited reference regarded reliable by OECD.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Aminopyridines
- Year:
- 2 005
- Bibliographic source:
- http://www.epa.gov/hsrb/files/meeting-materials/jun-27-29-2007-public-meeting/nci-2006.pdf
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No other information available from the data source
- GLP compliance:
- not specified
- Remarks:
- No other information available from the data source
Test material
- Reference substance name:
- 2-pyridylamine
- EC Number:
- 207-988-4
- EC Name:
- 2-pyridylamine
- Cas Number:
- 504-29-0
- Molecular formula:
- C5H6N2
- IUPAC Name:
- pyridin-2-amine
Constituent 1
Test organisms
- Test organisms (species):
- Salmonella typhimurium
Results and discussion
Any other information on results incl. tables
No other information available from the data source
Applicant's summary and conclusion
- Executive summary:
• 2-Aminopyridine was not mutagenic in Salmonella typhimurium TA98, TA100, TA1535, and TA1537 at concentrations up to 10,000 μg/plate. Mutagenicity was not enhanced by Aroclor-induced rat or hamster S-9
• 2-Aminopyridine was not mutagenic in Salmonella typhimurium TA98 in the presence or absence of S-9. Mutagenicity was not enhanced in the presence of norharman at 200 μg/plate with or without activation
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