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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May-July 1973
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Mice in the weight range 17 to 23 g were starved overnight before treatment with the substance.
The mice were treated with an emulsion of substance and vehicle and administered at a maxiumum dosage volume of 16 ml/kg bodyweight. Mice treated with vehicle served as control mice. During observation period of 14 days, a record was kept of all mortalities and signs of toxicity. All mice that died were examined macroscopically in an attemt to identify the target organs, and those animals surviving terminally were similarly examined to detect possible residual damage.
GLP compliance:
not specified
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
O,O-dimethyl phosphorochloridothioate
EC Number:
219-754-9
EC Name:
O,O-dimethyl phosphorochloridothioate
Cas Number:
2524-03-0
Molecular formula:
C2H6ClO2PS
IUPAC Name:
O,O-dimethyl chlorophosphonothioate

Test animals

Species:
mouse
Strain:
other: CFLP
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: Tween 80 (10% aqueous dilution)
Doses:
(ml/Kg):
0
0.25
0.4
0.64
1.0
1.6
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
0.77 mL/kg bw
Based on:
not specified
95% CL:
>= 0.66 - <= 0.9

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category I
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute median lethal oraldose (LD50) and its 95% confidence limits to mice of MP2 were calculated to be 0.77 (0.66-0.90) ml/kg bodyweight.