Registration Dossier
Registration Dossier
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EC number: 952-948-8 | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 November 2019 to 26 March 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181 CIPAC Handbook H (1998)
- Version / remarks:
- 1998
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Purity: 94.5 %
Storage Condition: Ambient temperature, cool and dry conditions, DEFITRACES. - Key result
- Medium:
- other: p-xylene
- Solubility:
- > 250 g/L
- Temp.:
- 20.26 °C
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 250 g/L
- Temp.:
- 20.26 °C
- Key result
- Medium:
- methanol
- Solubility:
- > 250 g/L
- Temp.:
- 20.26 °C
- Key result
- Medium:
- acetone
- Solubility:
- > 250 g/L
- Temp.:
- 20.26 °C
- Key result
- Medium:
- ethyl acetate
- Solubility:
- > 250 g/L
- Temp.:
- 20.26 °C
- Key result
- Medium:
- dimethylformamide
- Solubility:
- > 250 g/L
- Temp.:
- 20.26 °C
- Key result
- Medium:
- DMSO
- Solubility:
- > 250 g/L
- Temp.:
- 20.26 °C
- Test substance stable:
- yes
- Conclusions:
- 3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole is well soluble in semi-polar solvents (DMF, DMSO), in aromatic (p-xylene) and in halogenated solvents (dichloromethane) with a solubility of higher than 250 g/L.
- Executive summary:
The solubility of 3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole in several organic solvents is determined according to CIPAC MT 181 by adding successive measured volumes of solvent to a known mass of the test item until complete dissolution is observed. Solubility 3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole was determined as followed:
In p-xylene higher than 250 g/L.
In dichloromethane higher than 250 g/L.
In methanol higher than 250 g/L.
In acetone higher than 250 g/L.
In ethyl acetate is higher than 250 g/L.
In dimethylformamide higher than 250 g/L.
In dimethylsulfoxide higher than 250 g/L.
Reference
Description of key information
Solubility of 3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole in organic solvents was determined according to CIPAC 181 (1998).
3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole is well soluble in semi-polar solvents (DMF, DMSO), in aromatic (p-xylene) and in halogenated solvents (dichloromethane) with a solubility of higher than 250 g/L.
Key value for chemical safety assessment
Additional information
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