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EC number: 230-386-8 | CAS number: 7085-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 June 1986 to 27 August 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-1 (Hydrolysis)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The work conducted after 16 October 1989, was conducted in accordance with the EPA GLP Standards.
- Radiolabelling:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Definitive Study
The hydrolysis samples were analysed using procedures outlined. Sampling times were posted on a master calendar and were based on the results of the preliminary investigation, as well as previous analyses. After analysis, the hydrolysis samples were stored in a freezer. - Buffers:
- Solvent System A: Chloroform: hexane: glacial acetic acid (80:20:10)
Solvent System B: Toluene: methanol: glacial acetic acid (90:16:8)
Solvent System C: Acetonitrile: water: ammonium hydroxide (80:18:2)
pH 5 Buffer: 0.01 M sodium acetate adjusted to pH 4.99 and pH 5.00 with acetic acid for preliminary and definitive studies, respectively.
pH 7 Buffer: 0.01 M potassium phosphate adjusted to pH 7.00 and pH 7.00 with acetic acid for preliminary and definitive studies, respectively.
pH 9 Buffer: 0.01 M sodium borate adjusted to pH 9.00 and pH 9.01 with sodium hydroxide and/or acetic acid for preliminary and definitive studies, respectively. - Details on test conditions:
- Preliminary Investigation
Sample Preparation and Fortification: Aliquots (3.5 mL) of each aqueous buffer solution were placed in separate glass vials (three) and Spectro-cells (six). These were capped and autoclaved for 4 hours at 122 °C. To minimise the headspace, an additional 0.5 mL of each buffer solution was added for a total of 4.0 mL. To three of the Spectro-cells, 40 µL of acetone was added as a sensitiser. The glass vials were wrapped with aluminium foil. The fortification solution was prepared by mixing 14C-test material and analytical-grade test material in acetonitrile (ACN). Each vial and cell were fortified with 30 µL of the test material solution to obtain a final concentration of 41 ppm [1.2 µCi 14C-test material as determined by liquid scintillation counting (LSC)]. The cells and vials were placed in an inverted position between four Chroma 50 artificial lamps (two on each side) and maintained at approximately 25 °C.
Definitive Study
TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Glass vials and Spectro-cells. All vials and cells were labelled with a unique sample number, the study number, and a description of the matrix. For each of the three pH groups there were two sets of glass vials (five vials each) and two sets of Spectro-cells (five cells each).
- Sterilisation method: The cells and vials were sterilised by autoclaving for 4.25 hours at 122 °C.
- Measures taken to avoid photolytic effects: All glass vials were wrapped in aluminium foil to prevent light exposure.
TEST MEDIUM
- Preparation of test medium: Aliquots (4.0 mL) of each aqueous buffer solution were placed in separate cells and vials and capped. To one set of Spectro-cells at each pH, 40 µL of acetone was added as a sensitiser. The fortification solution was prepared by mixing 14C-test material and analytical-grade test material in ACN. Each vial and cell were fortified with 40 µL of the test material solution. Pre-, mid-, and post-fortification aliquots were removed from the test material solution to determine the amount of test material applied. The final concentrations in the cells and vials were 52 ppm (4.4 µCi) for the hydrolysis samples.
OTHER TEST CONDITIONS
- The hydrolysis vials were placed in the dark and maintained at 25 °C ± 2° C. Temperature was recorded using a Dickson Minicorder. - pH:
- 5
- Temp.:
- 25 °C
- Initial conc. measured:
- 52 other: ppm
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 52 other: ppm
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 52 other: ppm
- Number of replicates:
- Five
- Positive controls:
- no
- Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- The test material was hydrolytically stable for the study period.
- pH:
- 5
- Temp.:
- 25 °C
- Remarks on result:
- other: Hydrolytically stable for the study period.
- pH:
- 7
- Temp.:
- 25 °C
- Remarks on result:
- other: Hydrolytically stable for the study period.
- pH:
- 9
- Temp.:
- 25 °C
- Remarks on result:
- other: Hydrolytically stable for the study period.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the conditions of the study, the test material was hydrolytically stable for the study period.
- Executive summary:
The hydrolysis of the test material was assessed according to EPA Guideline N 161-1 and in compliance with GLP.
Hydrolysis vials containing the test material at 52 ppm at pH 5, pH 7 and pH 9 were placed in the dark and maintained at 25 °C ± 2° C. Temperature was recorded using a Dickson Minicorder.
Under the conditions of the study, the test material was hydrolytically stable for the study period.
Reference
Percent Recovery and Percent Test Material Remaining in Aqueous pH 5 Buffer Samples
Matrix |
Duration (Hours) |
Recovery (%) |
TLC Fraction of Test Material (%) |
Test Material Remaining (%) |
Hydrolysis |
5.4 |
105 |
96.91 |
102 |
107 |
106 |
97.61 |
103 |
|
194 |
106 |
92.57 |
98.1 |
|
345 |
107 |
97.47 |
104 |
|
751 |
108 |
9.27 |
103 |
Percent Recovery and Percent Test Material Remaining in Aqueous pH 9 Buffer Samples
Matrix |
Duration (Hours) |
Recovery (%) |
TLC Fraction of Test Material (%) |
Test Material Remaining (%) |
Hydrolysis |
1.4 |
50.6* |
96.96 |
N/C |
65.8 |
111 |
97.25 |
108 |
|
190 |
115 |
96.60 |
111 |
|
321 |
107 |
97.46 |
104 |
|
740 |
112 |
97.96 |
110 |
*: Low recoveries attributed to inadequate mixing. Values were not used in subsequent calculations.
N/C: No calculations performed.
Duration and Final pH Values for Aqueous pH 5 Buffer Samples
Matrix |
Duration (Hours) |
Final pH |
Hydrolysis |
5.4 |
5.02 |
107 |
4.98 |
|
194 |
4.02 |
|
345 |
5.00 |
|
751 |
4.97 |
Initial pH was determined to be 5.00
Duration and Final pH Values for Aqueous pH 7 Buffer Samples
Matrix |
Duration (Hours) |
Final pH |
Hydrolysis |
5.3 |
6.99 |
107 |
6.97 |
|
194 |
6.95 |
|
345 |
6.94 |
|
751 |
7.00 |
Initial pH was determined to be 7.00
Duration and Final pH Values for Aqueous pH 9 Buffer Samples
Matrix |
Duration (Hours) |
Final pH |
Hydrolysis |
1.4 |
8.96 |
65.8 |
8.96 |
|
190 |
8.97 |
|
321 |
8.98 |
|
740 |
8.93 |
Initial pH was determined to be 9.01
First Order Treatment of Percentage Test Material Remaining
Sample Description |
Y-intercept |
Slope |
Coefficient of Correlation |
Calculated Half Life (Hours) |
pH 5 hydrolysis |
2.01 |
7.01E-06 |
0.18622 |
N/C |
pH 7 hydrolysis |
2.03 |
-3.59E-06 |
-0.68915 |
N/C |
pH 9 hydrolysis |
2.03 |
5.4E-06 |
0.12389 |
N/C |
N/C: Half-life not calculated.
Description of key information
Key Study: Obrist (1986)
Under the conditions of the study, the test material was hydrolytically stable for the study period.
Key value for chemical safety assessment
Additional information
Key Study: Obrist (1986)
The hydrolysis of the test material was assessed according to EPA Guideline N 161-1 and in compliance with GLP. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).
Hydrolysis vials containing the test material at 52 ppm at pH 5, pH 7 and pH 9 were placed in the dark and maintained at 25 °C ± 2 °C. Temperature was recorded using a Dickson Minicorder.
Under the conditions of the study, the test material was hydrolytically stable for the study period.
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