Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-386-8 | CAS number: 7085-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Literature report of poisoning incident
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Treatment of severe 2,4-D and Mecoprop Intoxication with Alkaline Diuresis.
- Author:
- Prescott LF, Park J, Darrien I.
- Year:
- 1 979
- Bibliographic source:
- Br. J. Clin. Pharmac. (1979) 7: 111 – 116
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Report of a self-poisoning incident with a selective weedkiller in a 39 year old man.
- GLP compliance:
- no
- Remarks:
- Not applicable
Test material
- Reference substance name:
- Mecoprop
- EC Number:
- 230-386-8
- EC Name:
- Mecoprop
- Cas Number:
- 7085-19-0
- Molecular formula:
- C10H11ClO3
- IUPAC Name:
- 2-(4-chloro-2-methylphenoxy)propanoic acid
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- Weedkiller containing 20 % test material.
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: One
- Sex: Male
- Age: 39 - Ethical approval:
- not applicable
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
- Details on exposure:
- A 39 year old male was admitted to hospital 2 h after the deliberate ingestion of the contents of a lemonade bottle half full of weedkiller which was later shown to contain 20 % of the target material and 10 % 2,4-D.
- Examinations:
- Pulse rate
Blood pressure
Respiratory rate
Pupil reactivity
Muscle tone and tendon reflexes
Arterial blood analysis
Stimulation to pain
Clinical and radiological chest examination
Arterial oxygen
ECG
Electromyography
Analytical Methods:
Plasma and urine were acidified with 1 N HCl and the herbicides were extracted into 5 mL ether containing 2,4,5-trichlorophenoxyacetic acid as internal standard. The aqueous phase was discarded and the chlorophenoxy acids extracted back into 100 μL 0.1 < trimethylanilinium hydroxide in 50 % aqueous methanol. Aliquots 2 (μL) were injected into a HP Model 402 gas chromatograph fitted with a 4 ft x 1/4 in glass column packed with 10 % OV17 on Gaschrom Q. the injection port and oven temperature were 310 °C and 200 °C respectively and the carrier gas (nitrogen) flow rate was 60 mL/min. The chlorophenoxy acids were chromatographed as methyl esters formed by thermal decomposition in the injection port. The mean standard deviation of replicate assays of plasma and urine containing 10 – 100 μg/mL of test material was 5.3 %.
Total unchanged and conjugated chlorophenoxy acids in urine were estimated as above after hydrolysis with 3 N HCl at 80 °C for 1 h. The pKa of the test material was determined by titration.
Dose Absorbed:
The total amount of the test material recovered in the urine was 7.64 g. About 65 % of the test material was excreted as acid-labile conjugates. - Medical treatment:
Gastric aspiration and lavage were performed on admission.
Cooled with fans and tepid sponging.
An alkaline diuresis was induced after 40 h and over the next 48 h 14L fluid containing 69.3 g sodium bicarbonate was given intravenously while the central venous pressure was monitored.
Results and discussion
- Clinical signs:
- Soon after ingestion the patient vomited, became aggressive and confused and then rapidly lost consciousness. On admission the pulse rate and blood pressure were normal but the respiratory rate was 35/min with a minute volume of 121. The pupils were small but reactive, muscle tone was increased and tendon reflexes were normal. Arterial blood analysis showed mild metabolic acidosis and hypoxia (H+ 47 nmol, pCO2 3.6 kPa, bicarbonate 14 mmol/L and pO2 8.7 kPa).
Over the next few hours his condition deteriorated. He became unresponsive to painful stimuli, the tendon reflexes disappeared, the pulse rate increased to 140/min and the temperature rose to 39 °C. He was vasodilated and sweating profusely. Cyanosis was evident despite a respiratory rate of 40 – 50/ min and the chest was clear clinically and radiologically. A normal arterial oxygen tension could only be maintained with an M.C. mask and the temperature remained at 39 °C despite the use of fans and tepid sponging.
40 h after admission the patient was still deeply unconscious. Arterial blood analysis showed H+ 37 nmol/L, pCO2 5/1 kPa, pO2 5.4 kPa and bicarbonate 25.5 mmol/L with a minute volume of 141 and respiratory rate of 45/min. The chest was still clear and an ECG showed sinus tachycardia with T wave flattening in the standard leads and marked T wave inversion in the chest leads. The plasma urea had risen to 28.4 mmol/L despite good peripheral perfusion, as systolic blood pressure of 90 – 100 mmHg and a urine output of 2 - 3L/24 h.
Within a few hours of starting the alkaline diuresis the pulse rate, respiration rate and temperature began to fall and 18 h later he was responding readily to painful stimuli, deep tendon reflexes were brisk and marked myotonia was present. Consciousness was regained 4 days after admission, but he remained confused and disorientated for a further 4 days. The myotonia persisted for several days and there was marked proximal muscle weakness which lasted for several weeks.
By the 5th day the plasma urea had fallen to 5.6 mmol/L and the ECG reverted to normal. The creatinine clearance was 139 mL/min on the ninth day. There was biochemical evidence of severe muscle injury. The plasma creatinine phosphokinase (CPK) rose to > 3 000 u/L (normal < 180) and remained above this for several days and the urine gave a strongly positive test for haemoglobin. The plasma aminotransferase and lactic dehydrogenase activities were also elevated but the alkaline phosphatase and bilirubin remained within normal limits. Electromyography performed 6 days after ingestion showed changes consistent with mild myopathy. The patient was discharged to a psychiatric ward 11 days after admission and at follow up 2 months later was well but still complaining of some weakness of the legs. - Results of examinations:
- As listed in Clinical Signs.
- Effectivity of medical treatment:
- The plasma concentration of the test material on admission was 751 μg/mL. Over the next two days the concentration declined slowly with a half-life of about 40 h. There was a delay before the urine became alkaline after diuresis was started. The half life values just before, during and after the urine became alkaline was 24, 11 and 28 h respectively.
The measured pKa value was 2.8.
Muscle damage with myotonia was a major complication and the striking elevation of plasma CPK could not be attributed to coma alone. The generalised T wave abnormalities on the ECG suggest myocardial as well as skeletal muscle damage.
The patient remained gravely ill with no signs of improvement after two days of supportive therapy. The test material was extensively metabolised and although alkaline diuresis while worthwhile was less effective in enhancing its elimination than for 2,4-D. The pKA of the test material is 2.8, which is just below the critical value of 3.0 proposed for pH-dependent renal excretion of organic acids. - Outcome of incidence:
- The patient was discharged to a psychiatric ward 11 days after admission and at follow up 2 months later was well but still complaining of some weakness of the legs.
Applicant's summary and conclusion
- Conclusions:
- Self-poisoning with a selective weedkiller containing 20 % of the target material and 10 % 2,4-D in a 39 year old man resulted in prolonged deep coma, pyrexia, hyperventilation, hypoxia, myotonia, skeletal muscle damage and electrocardiographic changes consistent with cardiomyopathy. On admission, the plasma concentration of the target substance was 751 μg/L. The patient remained gravely ill with no sign of improvement for two days with supportive therapy, followed by induction of alkaline diuresis. The target substance was extensively metabolised and although alkaline diuresis was worthwhile it was less effective in enhancing its elimination than for 2,4-D. The pKA of the test material is 2.8, which is just below the critical value of 3.0 proposed for pH-dependent renal excretion of organic acids. The patient was discharged to a psychiatric ward 11 days after admission and at follow up 2 months later was well but still complaining of some weakness of the legs.
- Executive summary:
Self-poisoning with a selective weedkiller containing 20 % of the target material and 10 % 2,4-D in a 39 year old man resulted in prolonged deep coma, pyrexia, hyperventilation, hypoxia, myotonia, skeletal muscle damage and electrocardiographic changes consistent with cardiomyopathy. On admission, the plasma concentration of the target substance was 751 μg/L. The patient remained gravely ill with no sign of improvement for two days with supportive therapy. The target substance was extensively metabolised and although alkaline diuresis was worthwhile it was less effective in enhancing its elimination than for 2,4D. The pKA of the test material is 2.8, which is just below the critical value of 3.0 proposed for pH-dependent renal excretion of organic acids.
Consciousness was regained 4 days after admission, but he remained confused and disorientated for a further 4 days. The myotonia persisted for several days and there was marked proximal muscle weakness which lasted for several weeks.
By the 5th day the plasma urea had fallen to 5.6 mmol/L and the ECG reverted to normal. The creatinine clearance was 139 mL/min on the ninth day. There was biochemical evidence of severe muscle injury. The plasma creatinine phosphokinase (CPK) rose to > 3 000 u/L (normal < 180) and remained above this for several days and the urine gave a strongly positive test for haemoglobin. The plasma aminotransferase and lactic dehydrogenase activities were also elevated but the alkaline phosphatase and bilirubin remained within normal limits. Electromyography performed 6 days after ingestion showed changes consistent with mild myopathy. The patient was discharged to a psychiatric ward 11 days after admission and at follow up 2 months later was well but still complaining of some weakness of the legs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.