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Diss Factsheets
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EC number: 201-550-6 | CAS number: 84-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review paper from peer reviewed journal
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients
- Author:
- Api AM
- Year:
- 2 000
- Bibliographic source:
- Food and chemical toxicology 39: 97-108 2001
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Principles of method if other than guideline:
- Oral administration of 14C DEP to rats and mice and subsequent analysis of radio activity levels in kidney liver blood spleen and fat.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethyl phthalate
- EC Number:
- 201-550-6
- EC Name:
- Diethyl phthalate
- Cas Number:
- 84-66-2
- Molecular formula:
- C12H14O4
- IUPAC Name:
- .
- Details on test material:
- - Name of test material (as cited in study report): diethyl phthalate
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C14
Test animals
- Species:
- other: rats & mice
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- None
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on exposure:
- None
- Duration and frequency of treatment / exposure:
- Not specified
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not specified
- No. of animals per sex per dose / concentration:
- Not specified
- Control animals:
- not specified
- Details on study design:
- Not specified
- Details on dosing and sampling:
- Not specified
- Statistics:
- Not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not reported
- Details on distribution in tissues:
- maximum concentrations of radio activity in kidney liver blood spleen & fat were observed within 20 minutes of administration followed by a decrease to trace levels 24h after dosing. Excretion occured primarily via the urine. Cumulative urinary & faecal excretion respectively were 47 & 0.7% within 12h, 82 & 2.5% within 24h & 90 & 2.7% within 48h after dosing.
Transfer into organs
- Transfer type:
- secretion via gastric mucosa
- Observation:
- distinct transfer
- Details on excretion:
- Excretion occured primarily via the urine. Cumulative urinary & faecal excretion respectively was 47 & 0.7% within 12h, 82 & 2.5% within 24h & 90 & 2.7% within 48h after dosing.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
A study of the absorption, distribution, metabolism and elimination of diethyl phthalate reports that approximately 90% of radioactivity from an administered dose was excreted in the urine within 48 hours following oral administration of14C-DEP to rats and mice, with the majority (82%) being eliminated during the first 24 hours. Approximately 3% of the radioactivity was found in the faeces over the same period of time. Radioactivity was widely distributed with the highest concentrations observed in kidney and liver, followed by blood, spleen and adipose tissue. Highest levels were noted within 20 minutes, followed by a rapid decrease to only trace amounts after 24 hours. The mono-ester (MEP) was the major urinary metabolite identified and phthalic acid was identified as a minor secondary metabolite. - Executive summary:
A study of the absorption, distribution, metabolism and elimination of diethyl phthalate reports that approximately 90% of radioactivity from an administered dose was excreted in the urine within 48 hours following oral administration of14C-DEP to rats and mice, with the majority (82%) being eliminated during the first 24 hours. Approximately 3% of the radioactivity was found in the faeces over the same period of time. Radioactivity was widely distributed with the highest concentrations observed in kidney and liver, followed by blood, spleen and adipose tissue. Highest levels were noted within 20 minutes, followed by a rapid decrease to only trace amounts after 24 hours. The mono-ester (MEP) was the major urinary metabolite identified and phthalic acid was identified as a minor secondary metabolite.
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