Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

There are no reports on sensitisation caused by strontium chromate, but zinc chromate-containing primers have been reported to cause allergic contact dermatitis in humans. Moreover, soluble chromates show positive results in several animal skin sensitisation tests. Some case reports, supported by bronchial challenge tests, indicate that hexavalent chromium compounds may induce respiratory sensitisation, including occupational asthma. Strontium chromate has previously not been classified for sensitisation. Zinc chromate is currently classified for skin sensitisation (Skin Sens. 1), and soluble chromates are classified both for skin and respiratory sensitisation (Skin Sens. 1, Resp. Sens. 1). Based on read-across from zinc chromate, strontium chromate should also be classified as skin sensitiser.


Migrated from Short description of key information:
There are no reports on sensitisation caused by strontium chromate, but zinc chromate-containing primers have been reported to cause allergic contact dermatitis in humans.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Strontium chromate has not been reported to cause respiratory sensitisation. Data on respiratory sensitisation caused by zinc chromate is limited to a few old case reports, and compared to the amount of workers potentially exposed to various sparingly soluble chromates, the number of reported cases can be considered as very low. Other cases of occupational asthma have been reported among metalplating workers exposed to highly soluble chromium compounds. Some of these cases were evaluated and confirmed by bronchial challenge tests.

At the moment, there are no validated test methods for respiratory sensitisation

No sparingly soluble chromates have previously been classified as respiratory sensitizers, but highly soluble chromates are classified for respiratory sensitisation under EU.

Migrated from Short description of key information:
There are no data on respiratory sensitisation caused by strontium chromate. No case reports have either been found on respiratory sensitisation of any sparingly soluble chromates.

Justification for classification or non-classification

Strontium chromate is suggested to be classified for skin sensitisation, based on read-across from zinc chromate, which is currently classified as a skin sensitising substance.

Due to the lack of data on respiratory sensititsation caused by strontium chromate or other sparingly soluble chromates, and the lack of appropriate test methods, no classification is suggested for respiratory sensitisation.