Registration Dossier
Registration Dossier
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EC number: 204-706-1 | CAS number: 124-63-0
Endpoint summary
Administrative data
Description of key information
repeated dose toxicity oral: Eastman Kodak, 1978, 2 weeks daily administration by gavage - LOAEL 50 mg/kg bw
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 50 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
Rats were given daily gavages of 100 mg/kg or 50 mg/kg methanesulfonyl chloride for 2 weeks. All animals lost weight and failed to eat normally. Three of the five animals given 100 mg/kg died within six days. The remaining two were discarded. All animals developed discolored (green) urine.
Beside weight loss, discolored (green) urine, increase in circulating white blood cells, depressed glutamic pyruvic transaminase and alkaline phosphatase values, depressed absolute liver and kidney weights at the LOAEL 50 mg/kg bw, the test animals also showed severe necrotizing esophagitis and gastritis with or without ulceration at the same test concentration.
Therefore methanesulfonyl chloride can be described as a severe tissue irritant.
Justification for classification or non-classification
The results of the 2 weeks repeated dose oral toxicity study in rats confirm the assessment of methanesulfonyl chloride beeing a severe skin irritant (for further information see endpoint summary "Irritation/corrosion"). Furthermore, it can be expected to cause necrosis of any tissue with which it comes in contact.
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