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EC number: 204-706-1 | CAS number: 124-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2nd December 2009 to 30th december 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study with dated and signed quality assurance inspection statement included.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EC) n. 440/2008 of 30 May lying down methods pursuant to regulation (EC) n. 1907/2006
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methanesulphonyl chloride
- EC Number:
- 204-706-1
- EC Name:
- Methanesulphonyl chloride
- Cas Number:
- 124-63-0
- Molecular formula:
- CH3ClO2S
- IUPAC Name:
- methanesulfonyl chloride
- Details on test material:
- Chemica name: methanesulfonyl chloride (MSC)
batch n. 096260041
Molecular formula: CH3SO2Cl
Molecular weight: 114.55 g/mol
Purity: 99.8%
Appaerance: water white to light yellow liquid
date of production: July 2009
Expiry date: july 2011
Storage condition: room temeperature 15-25°C (humidity ca.50%) and protect by light.
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Details on inoculum:
- The inoculum: Activated sludge, microorganisms from a domestic waste water treatment plant.
Origin: The activated sludge was supplied from the sewage plant for domestic sewage in Veszprém, Hungary.
Conditioning: The activated sludge used for this study was washed by centrifugation (for 10 min.) and the supernatant liquid phase was decanted. The solid material was re-suspended in isotonic saline solution and again centrifuged (for 10 min.). This procedure was repeated twice. An aliquot of the final sludge suspension was weighed, dried and the ratio of wet sludge to its dry weight was determined. Based on this ratio, calculated aliquots of washed sludge suspension, corresponding to 4 g dry material per litre were mixed with test water (see below) and then aerated until use. Before use the sludge was filtered through cotton wool. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 8 mg/L
- Based on:
- other: ThOD(NO3) of 0.56 O2/mg test item ( calculated according to equation given in the guidelines) and on the performed 14-d preliminary test.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- the biodegradation was followed by the oxygen uptake of the microorganisms durin exposure.
- Details on study design:
- The test was carried out in an incubator and controlled environment room (during the formulation and oxygen measuring) at a temperature of 22.2°C according to guideline. The test flasks were placed into an incubator and kept at 21.6-22.8 C, in the dark. The temperature was measured on weekdays during the experiment. The oxygen concentration of test water was 8.6 mg/L at the start of the test. The pH value of the test water was checked prior study start. The pH of the test water was 7.37. The test conditions were measured with suitable instruments and documented in the raw data.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Preliminary study:
- It has been conducted a preliminary test as follows:
The concentration level (10.7 mg/L) investigated in the non-GLP preliminary test was chosen based on the ThOD NO3 of 0.56 mg O 2 /mg test item. The respective amount of Methanesulfonyl Chloride was weighed in directly to reach the required test item concentration of 10.7 mg/L. The duration of the preliminary test was 14 days. In the toxicity control containing both, the test item and the reference item, a mean of 38.0 % biodegradation was noted within 14 days and the test item could be assumed to not inhibit (higher than 25 % degradation occurred within 14 days) the activated sludge microorganisms at the examined concentration level of 10.7 mg/L. The percentage biodegradation of Methanesulfonyl Chloride reached a mean of 75.3 % after 14 days based on its ThOD NO3 in the preliminary study. According to the test guidelines the pass level for ready biodegradability is removal of 60 % ThOD NO3 . The concentration of dissolved oxygen resulted a mean of 2.85 mg O 2 /L after 14 days of incubation in the test item flasks (1a and 1b). According to the test guidelines the residual oxygen concentration in the test flasks will not drop below 0.5 mg O 2 /L at any time. Based on these reasons a lower test item contcentration had been required in the main test. - Test performance:
- Main test:
Before the preparation of the respective test solutions with Methanesulfonyl Chloride an aqueous stock solution of Methanesulfonyl Chloride with a concentration of 80 mg/L was prepared and diluted accordingly. The test item concentration in the test solutions was 8.0 mg/L. The chosen test item concentration is based on the theoretical oxygen demand (ThOD NO3 ) of 0.56 mg O 2 /mg test item (calculated according to equation given in the guidelines) and on the performed 14-d preliminary test. During the performance of the test, the test solutions were ultrasonicated for < 10 min. to ensure a good dispersion. The components were applied in the amounts/volumes following ratio in the test flasks:
Test Item:
The test item stock solution* corresponding to 27.68 mg of Methanesulfonyl Chloride was mixed into 3.46 litres of aqueous test medium (corresponding to 8.0 mg/L test item, respectively a ThOD NO3 of about 4.48 mg O 2 /L).
Procedure control: sodium benzoate:
The reference substance stock solution** corresponding to 12.096 mg of Sodium benzoate was mixed into 3.36 litres of aqueous test medium (corresponding to 3.6 mg/L reference item, respectively a ThOD NH4 of about 6.012 mg O 2 /L).
Inoculum control:
Only filtered inoculum was added to 3.40 litres of aqueous test medium.
Toxicity control:
Methanesulfonyl Chloride stock solution* (346 mL) and reference item stock solution** (34.6 mL) were mixed into 3.46 litres of aqueous test medium corresponding to 8.0 mg/L test item (ThOD NO3 of 4.48 mg O 2 /L) and 3.6 mg/L reference item (ThOD NH4 of 6.012 mg O 2 /L).
* The concentration of the test item stock solution
** The concentration of the stock solution was: 360 mg/L.
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 10.1
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 70.5
- Sampling time:
- 17 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 85
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 88.4
- Sampling time:
- 21 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 90.6
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Percentage degradation at different time intervals during the exposure period of 28 days:
% Degradation Parameter Sampling time
66.7 O2 consumption 7 d
73.3 O2 consumption 14 d
75.8 O2 consumption 17 d
Any other information on results incl. tables
Dissolved Oxygen Concentrations at Different Time Intervals during the Exposure Period of 28 Days:
Treatment |
Concentration [mg/L] |
Flask N. |
Mg O2/L after n days of exposure |
|||||
0 |
7 |
14 |
17 |
21 |
28 |
|||
Test item |
8.0 |
1a |
8.6 |
7.0 |
4.4 |
3.7 |
3.4 |
3.1 |
1b |
8.5 |
7.2 |
4.4 |
3.5 |
3.4 |
3.3 |
||
mean |
8.55 |
7.10 |
4.40 |
3.60 |
3.40 |
3.20 |
||
Reference item |
3.6 |
1a |
8.5 |
3.5 |
3.1 |
2.9 |
2.7 |
2.3 |
1b |
8.5 |
3.5 |
3.1 |
2.7 |
2.4 |
2.1 |
||
mean |
8.50 |
3.50 |
3.10 |
2.55 |
2.55 |
2.20 |
||
Inoculum control |
- |
1a |
8.7 |
7.7 |
7.7 |
7.5 |
7.5 |
7.4 |
1b |
8.6 |
7.6 |
7.6 |
7.5 |
7.4 |
7.3 |
||
mean |
8.65 |
7.65 |
7.65 |
7.50 |
7.45 |
7.35 |
||
Toxicity control |
Test item: 8.0 Ref. Item: 3.6 |
1a |
8.5 |
4.0 |
2.3 |
2.0 |
1.5 |
1.0 |
1b |
8.5 |
3.8 |
2.4 |
2.0 |
1.3 |
1.9 |
||
mean |
8.50 |
3.90 |
2.35 |
2.00 |
1.40 |
0.95 |
Oxygen depletion at different time intervals during the exposure period of 28 days:
Treatment |
Concentration [mg/L] |
Flask N. |
mg O2/L after n days of exposure |
|||||
7 |
14 |
17 |
21 |
28 |
|
|||
Test item |
8.0 |
1a |
0.60 |
3.20 |
3.75 |
4.00 |
4.20 |
|
1b |
0.30 |
3.10 |
3.85 |
3.90 |
3.90 |
|
||
Reference item |
3.6 |
1a |
4.0 |
4.40 |
4.45 |
4.60 |
4.90 |
|
1b |
4.0 |
4.40 |
4.65 |
4.90 |
5.10 |
|
||
Toxicity control |
Test item: 8.0 Ref. Item: 3.6 |
1a |
3.50 |
5.20 |
5.35 |
5.80 |
6.20 |
|
1b |
3.70 |
5.10 |
5.35 |
6.00 |
6.30 |
|
oxygen depletion : (mt0 - mtx) - (mbo - mbx),
where:
mt0 : oxygen concentration (mg/L) of test group on day 0
mtx: oxygen concentration (mg/L) of test group on day x
mb0: oxygen concentration (mg/L) of inoculum blank on day 0
mbx: oxygen concentration (mg/L) of inoculum blank on day x
BOD at different time intervals during the exposure period of 28 days:
Treatment |
Concentration [mg/L] |
Flask N. |
mg O2/L after n days of exposure |
|||||
7 |
14 |
17 |
21 |
28 |
|
|||
Test item |
8.0 |
1a |
0.08 |
0.40 |
0.47 |
0.50 |
0.53 |
|
1b |
0.04 |
0.39 |
0.48 |
0.49 |
0.49 |
|
||
Reference item |
3.6 |
1a |
1.11 |
1.22 |
1.24 |
1.28 |
1.36 |
|
1b |
1.11 |
1.22 |
1.29 |
1.36 |
1.42 |
|
||
Toxicity control |
Test item: 8.0 Ref. Item: 3.6 |
1a |
0.30 |
0.45 |
0.46 |
0.50 |
0.53 |
|
1b |
0.32 |
0.44 |
0.46 |
0.52 |
0.54 |
|
BOD = (mg O2 of T.i. and/or R.i– mg O2 of i. control) / (mg T.i. and/or R.i.in flask) = mgO2/mg T.i. and or R.i.
where: T.i. = test item
R.i. = reference item
i.control = inoculum control
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
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