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EC number: 203-924-4 | CAS number: 111-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD401; no individual data reported
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only one sex tested, limitations in study reporting
- Principles of method if other than guideline:
- acute oral toxicity after single application
- GLP compliance:
- no
- Remarks:
- performed before GLP guidelines
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethylenglykol-dimethylether
- IUPAC Name:
- Diethylenglykol-dimethylether
- Reference substance name:
- Bis(2-methoxyethyl) ether
- EC Number:
- 203-924-4
- EC Name:
- Bis(2-methoxyethyl) ether
- Cas Number:
- 111-96-6
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 1-methoxy-2-(2-methoxyethoxy)ethane
- Details on test material:
- - Name of test material (as cited in study report): Diethylenglykol-dimethylether
- Analytical purity: not stated
- physical state: clear colourless liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Hoe WISKf(SPF71)
- Source: Hoechst AG Kastengrund - SPF breed
- Weight at study initiation: 180-200 g (female); (mean = 191,0 g; s = ± 6,95; n = 60)
- Age at study initiation: no data
- Fasting period before study: 16 hours before and 2 hours after application
- Diet: Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum
- Water: Tap water ad libitum
- Acclimatization period: no data
ENVIRONMENTAL CONDITIONS
- Housing: in groups, in plastic cages, wood shavings
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - concentration in vehicle: 25 % (w/v)
- Doses:
- 1600, 2500, 4000, 4500, 5600, 6300 mg/kg bw
- No. of animals per sex per dose:
- 10 female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations after application / Weighing once weekly
- Necropsy of survivors performed: yes - Statistics:
- Probit analysis (method by Linder and Weber);
Confidence limits according to Fieller
Results and discussion
- Preliminary study:
- Preliminary experiments showed higher sensitiveness for females. Therefore only females were used for the main study.
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 760 mg/kg bw
- 95% CL:
- > 4 450 - < 5 160
- Mortality:
- Sex: female, Dose: 1600 mg/kg bw, Mortality rate: 0 / 10
Sex: female, Dose: 2500 mg/kg bw, Mortality rate: 0 / 10
Sex: female, Dose: 4000 mg/kg bw, Mortality rate: 0 / 10
Sex: female, Dose: 4500 mg/kg bw, Mortality rate: 4 / 10
Sex: female, Dose: 5600 mg/kg bw, Mortality rate: 9 / 10
Sex: female, Dose: 6300 mg/kg bw, Mortality rate: 10 / 10 - Clinical signs:
- other: Mortally poisened animals died within 1-4 days after application. Following symptoms were observed: agitation, disturbance of equilibrium, prone position, slow breathing, noisy respiration. Animals of the dose groups 1600 - 4000 mg/kg bw showed no symptom
- Gross pathology:
- Dissection of rats killed at the end of the observation period revealed no macroscopic findings.
Necropsy of the deceased animals revealed following macroscopic findings: grey-red coloured, partially dark-red speckled lungs, slight liver lobule markings in some animals.
Stomach tight filled with feed, adrenal dicoloured dark-red, blood-vessels injected, small intestine filled with red brown serous liquid, small intestine strongly reddened, pin-head sized ulcerations in stomach wall.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The median lethal dose of Diethyleneglycol-dimethylether (LD50) was 4760 mg per kg body weight. Based on the result of this study Diethyleneglycol-dimethylether is not subject for labelling and classification requirements according to regulatory requirements.
- Executive summary:
The median lethal dose of Diethyleneglycol-dimethylether (LD50) was 4760 mg per kg body weight. Based on the result of this study Diethyleneglycol-dimethylether is not subject for labelling and classification requirements according to regulatory requirements.
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