Trichloro(N,N-dimethyloctylamine)boron

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Similar study to OECD 402, non-GLP. Number of animals treated is not mentioned.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Trichloro(N,N-dimethyloctylamine)boron

EC Number:

252-200-4

EC Name:

Trichloro(N,N-dimethyloctylamine)boron

Cas Number:

34762-90-8

Molecular formula:

C10H23BCl3N

IUPAC Name:

dimethyl(octyl)(trichloro-λ⁵-boranylidene)amine

Test material form:

solid: crystalline

Details on test material:

A yellowish-white semi crystaline solid, labelled TK 12146.
ZK 502.3942. Op. 1/76 K650. 16.9.76.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Rats were caged singly and kept in a room maintained at a temperature of 21°C. (+.2°). Animals were subjected to 12 hours artificial light and 12 hours darkness in each 24 hour period.
A commercial pelleted diet (Oakes Special Diet with added Uit. E) was fed ad lib. Water was available at all times.

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

The animals were prepared and the compound applied according to the method suggested in Working Document No. 14 of the Pesticides Safety Precautions Scheme, published by the Ministry of Agriculture, Fisheries and Food, Pesticides Branch, Great Uestminster House, Horseferry Road, London, S.W.1.
The compound was applied as supplied at the rate of 2.5ml/kg.

Doses:

2.5 ml/kg

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2.5 mL/kg bw

Based on:

test mat.

Mortality:

No death occurred during the course of the study.

Clinical signs:

other: No clinical signs were noted during the course of the study.

Gross pathology:

No changes in organs or tissues were noted at the end necropsy.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Under the study conditions, the acute dermal LD50 was determined to be 2.5 mL/kg.

Executive summary:

A Study was conducted to determine the acute dermal toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron, to Sprague-Dawley rats in a Guideline similar to OECD Guideline 402 without GLP. Rats were administered unchanged test substance at a level of 2.5 mL/kg. All animals were observed for mortality, clinical signs and gross pathological changes. No treatment related mortality, clinical signs or gross pathological changes were observed during course of study. Under the study conditions, the acute dermal LD50 was determined to be 2.5 mL/kg (Hess, 1976).