Trichloro(N,N-dimethyloctylamine)boron

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Similar to OECD 401 study performed pre-GLP.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Rats were caged singly and kept in a room maintained at a temperature of 21°C. (^2°). Animals were subjected to 12 hours artificial light and 12 hours darkness in each 24 hour period.
A commercial pelleted diet (Oakes Special Diet with added Vit. E) was fed ad lib. Water was available at all times.

Route of administration:

oral: gavage

Vehicle:

polyethylene glycol

Details on oral exposure:

A 25% w/v solution of the compound in polyethylene glycol was administered as a single dose by gavage to rats which had been fasted for 18 hours, at a rate of 20 ml/kg.

Doses:

5000 mg/kg

No. of animals per sex per dose:

5 males and 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily for clinical signs and deaths
- Necropsy of survivors performed: yes

Statistics:

no statistics performed

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occured during the course of the study.

Clinical signs:

other: No clinical signs were noted during the course of the study.

Gross pathology:

No changes were noted in organs or tissue at the final necropsy.

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Under the study conditions, the LD50 of trichloro(N,N-dimethyloctylamine)boron was > 5000 mg/kg bw after single oral administration to rats.

Executive summary:

A study was conducted to determine the acute oral toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron in Guideline similar OECD Guideline 401 without GLP. The substance was administered by oral gavage to Sprague Dawley rats (5/sex/group) at 5000 mg/kg bw. Treated animals were observed for mortality and clinical signs for 14 day observation period and were then subjected to gross pathological examination. No mortality and no clinical signs were observed during the study. Under the study conditions, the LD50 of trichloro(N,N-dimethyloctylamine)boron was > 5000 mg/kg bw after single oral administration to rats (Hess, 1976).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Similar study to OECD 402, non-GLP. Number of animals treated is not mentioned.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Rats were caged singly and kept in a room maintained at a temperature of 21°C. (+.2°). Animals were subjected to 12 hours artificial light and 12 hours darkness in each 24 hour period.
A commercial pelleted diet (Oakes Special Diet with added Uit. E) was fed ad lib. Water was available at all times.

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

The animals were prepared and the compound applied according to the method suggested in Working Document No. 14 of the Pesticides Safety Precautions Scheme, published by the Ministry of Agriculture, Fisheries and Food, Pesticides Branch, Great Uestminster House, Horseferry Road, London, S.W.1.
The compound was applied as supplied at the rate of 2.5ml/kg.

Doses:

2.5 ml/kg

Control animals:

not specified

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2.5 mL/kg bw

Based on:

test mat.

Mortality:

No death occurred during the course of the study.

Clinical signs:

other: No clinical signs were noted during the course of the study.

Gross pathology:

No changes in organs or tissues were noted at the end necropsy.

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Under the study conditions, the acute dermal LD50 was determined to be 2.5 mL/kg.

Executive summary:

A Study was conducted to determine the acute dermal toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron, to Sprague-Dawley rats in a Guideline similar to OECD Guideline 402 without GLP. Rats were administered unchanged test substance at a level of 2.5 mL/kg. All animals were observed for mortality, clinical signs and gross pathological changes. No treatment related mortality, clinical signs or gross pathological changes were observed during course of study. Under the study conditions, the acute dermal LD50 was determined to be 2.5 mL/kg (Hess, 1976).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 500 mg/kg bw

Additional information

Acute oral toxicity

A study was conducted to determine the acute oral toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron in Guideline similar OECD Guideline 401 without GLP. The substance was administered by oral gavage to Sprague Dawley rats (5/sex/group) at 5000 mg/kg bw. Treated animals were observed for mortality and clinical signs for 14 day observation period and were then subjected to gross pathological examination. No mortality and no clinical signs were observed during the study. Under the study conditions, the LD50 of trichloro(N,N-dimethyloctylamine)boron was > 5000 mg/kg bw after single oral administration to rats (Hess, 1976).

Acute Dermal toxicity

A Study was conducted to determine the acute dermal toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron, to Sprague-Dawley rats in a Guideline similar to OECD Guideline 402 without GLP. Rats were administered unchanged test substance at a level of 2.5 mL/kg. All animals were observed for mortality, clinical signs and gross pathological changes. No treatment related mortality, clinical signs or gross pathological changes were observed during course of study. Under the study conditions, the acute dermal LD50 was determined to be 2.5 mL/kg (Hess, 1976).

Justification for classification or non-classification

Based on the acute oral and dermal toxicity study results the substance does not need to be classified according to EU CLP regulation (EC) 1272/2008.