Registration Dossier
Registration Dossier
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EC number: 205-451-9 | CAS number: 141-05-9
Endpoint summary
Administrative data
Description of key information
GLP studies on skin and eye irritation: no classification required.
Literature data (animal studies, different test condicitons): slightly to moderately irritant.
Literature data on tests with humans: not irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
One GLP- and guidelinen compliant key study (dated 1999) describes slightly irritating effects to the skin of rabbits. All effects were slight to moderate and were fully reversible within 48 hours.
A study (dated 1975) with human volunteers with administration to the skin for 48 hours under occlusive conditions did not elicit irritative effects.
1975 moderate effects were found in an animal study with occlusive administration to the skin for 24 hours and 1963 slightly irritating effects were found in another animal study (detailed data missing).
It is therefore concluded that no classification has to be derived for the test material.
Eye irritation
One GLP- and guideline compliant study (dated 1999) describes transient irritative effects to the eyes of rabbits which were fully reversible within 72 hours after administration.
1963 slightly irritating effects to the eyes of rabbits were found in another animal study (detailed data missing).
It is therefore concluded that no classification has to be derived for the test material.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the results of the most recent GLP studies and supported by older literature data no classification is derived for the test material.
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