Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-451-9 | CAS number: 141-05-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- in or before 1963
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Handbook data, no details available
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Esters
- Author:
- Fassett DW
- Year:
- 1 963
- Bibliographic source:
- In: Industrial Hygiene and Toxicology, 2nd Ed. Edited by Patty FA, Vol II, pa. 1895, Interscience Publishers, New York
- Reference Type:
- secondary source
- Title:
- Monographs on Fragrance Raw Materials, Diethyl Maleate
- Author:
- Opdyke DLJ
- Year:
- 1 976
- Bibliographic source:
- Fd Cosmet. Toxicol. Vol 14, pp 443-444, Pergamon Press
Materials and methods
- Principles of method if other than guideline:
- no guideline stated
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Diethyl maleate
- EC Number:
- 205-451-9
- EC Name:
- Diethyl maleate
- Cas Number:
- 141-05-9
- Molecular formula:
- C8H12O4
- IUPAC Name:
- diethyl (Z)-but-2-enedioate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- other: saturated vapours
- Remarks on result:
- other: According to DSM, the saturated vapours of the substance correspond to a concentration of 1 mg/L air.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No mortalities occurred after exposure of rats to saturated vapours of diethyl maleate for 8 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
