Registration Dossier
Registration Dossier
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EC number: 619-682-1 | CAS number: 224049-04-1
Endpoint summary
Administrative data
Description of key information
Skin irritation (OECD 404): not a skin irritant
Eye irritation (OECD 405): not an eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
To evaluate the skin irritation potential of the test substance, a study was performed according to OECD 404 (Nakamura, 2005a). No skin irritating or systemic effects were seen during the 72 -hr observation period following exposure to the test substance. Therefore, the test substance is considered not to be skin irritating.
To evaluate the eye irritation potential of the test substance, a study was performed according to OECD 405 (Nakamura, 2005b). A mild discharge from the eye of one animal was observed 1 hr after instilling 0.1 mL of the test substance into the eye. The reaction was fully reversible within 24 hours. The other two animals did not have any eye irritation reactions during the observation period. Based on the results of the study, the test substance does not cause eye irritation.
Justification for selection of skin irritation / corrosion endpoint:
The reliable GLP compliant OECD Guideline study was chosen.
Justification for selection of eye irritation endpoint:
The reliable GLP compliant OECD Guideline study was chosen.
Justification for classification or non-classification
The available data are conclusive but not sufficient for classification according to the criteria of DSD (67/548/EEC) and CLP (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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