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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-057-1 | CAS number: 102-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (BASF test, no details on animal husbandry, occlusive conditions, exposure period up to 20 hours)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-dibutylaminoethanol
- EC Number:
- 203-057-1
- EC Name:
- 2-dibutylaminoethanol
- Cas Number:
- 102-81-8
- Molecular formula:
- C10H23NO
- IUPAC Name:
- 2-(dibutylamino)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dibutylaethanolamin
- Analytical purity: >99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.55, 3.7 kg
No further data.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- No data
- Duration of treatment / exposure:
- 1, 5 and 15 min and 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol (conc.) and Lutrol/water (1:1).
- Time after start of exposure: Immediately after 1, 5 and 15 min exposure.
SCORING SYSTEM: The original BASF grading was converted into the numerical grading according the OECD Draize system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: 20 h exposure
- Time point:
- other: 24 h - 48 h -72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: Grey-brown necrosis was observed in the 20 h exposure experiment 24 hours after application. Necrosis still was evident at the end of the observation period of 8 days
- Irritation parameter:
- erythema score
- Remarks:
- 1 and 5 min exposure
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days in one of the two animals
- Irritation parameter:
- edema score
- Remarks:
- 1, 5 and 15 min exposure
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
Any other information on results incl. tables
Mean erythema score after 24, 48 and 72 h (animal 1/2)
Exposure time |
24 h |
48 h |
72 h |
mean |
1 min |
0/0 |
0/0 |
0/1 |
0/0.3 |
5 min |
0/0 |
0/0 |
0/1 |
0/0.3 |
15 min |
1/0 |
0/1 |
0/2 |
0.3/1 |
20 h |
grey-brown necrosis with reddened surrounding/ brown necrosis with reddened surrounding |
grey-brown necrosis with reddened surrounding/ brown necrosis with reddened surrounding |
grey-brown necrosis with reddened surrounding/ brown necrosis with reddened surrounding |
- /- |
Mean edema score after 24, 48 and 72 h (animal 1/2)
Exposure time |
24 h |
48 h |
72 h |
mean |
1 min |
0/0 |
0/0 |
0/0 |
0/0 |
5 min |
0/0 |
0/0 |
0/0 |
0/0 |
15 min |
0/0 |
0/0 |
0/0 |
0/0 |
20 h |
grey-brown necrosis with reddened surrounding/ brown necrosis with reddened surrounding |
grey-brown necrosis with reddened surrounding/ brown necrosis with reddened surrounding |
grey-brown necrosis with reddened surrounding/ brown necrosis with reddened surrounding |
- /- |
20 h exposure: necrosis was accompanied with bleedings.
The findings after 20 h occluded application were used for evaluation. The conclusion may be more stringent than one derived from a 4 h semi occluded application required by the current OECD guideline.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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