2-dibutylaminoethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

(BASF test, no details on animal husbandry and weight development)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-dibutylaminoethanol

EC Number:

203-057-1

EC Name:

2-dibutylaminoethanol

Cas Number:

102-81-8

Molecular formula:

C10H23NO

IUPAC Name:

2-(dibutylamino)ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): Dibutylaethanolamin
- Analytical purity: >99%

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 255 g (mean males), 189 g (mean females)
No further data.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: aqueous emulsion with traganth

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: The doses were administered as aqueous emulsions with traganth of 2% (200 mL/kg), 4% (400, 500, 640 mL/kg), 8% (800 mL/kg) and 20% (1600 mL/kg) test substance.

Doses:

200, 400, 500, 640, 800, 1600 mL/kg bw (172, 344, 430, 550, 688, 1376 mg/kg bw - conversion in mg/kg is based on the density: d= 0.8601 g/cm³).

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: before the start of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 550 - < 688 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Corresponds to 640 / 800 mL/kg bw; the mg/kg was calculated by means of the density: d= 0.8601 g/cm³; 688 mg/kg bw: all animals died within 1 hour post application; 550 mg/kg bw: no animal died

Mortality:

688, 1376 mg/kg bw: all animals died within 1 hour post application
430, 550 mg/kg bw: no animal died
344 mg/kg bw: 1 female animal died within one hour post application
172 mg/kg bw: no animal died

Clinical signs:

other: 688, 1376 mg/kg bw: Immediately after application tremor, convulsion, sounds of pain, dyspnoea, secretion out of the oral cavity were observed until death. 430, 550 mg/kg bw: Immediately after application tremor, convulsion, sounds of pain, dyspnoea, secr

Gross pathology:

Animals that died: extended blood content in the liver and blood in the intestinal loops was observed.
Animals that were sacrificed at the end of the study: bronchitis and bronchiectasis (430, 550 mg/kg bw). No further abnormalities were detected.