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EC number: 293-927-7
CAS number: 91648-65-6
No toxicity observed even at highest concentration level tested.OECD 203_Pimephales promelas: LL50(96h) > 1000 mg/L RA_ 1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-dodecanethiol_OECD 203_Leuciscus idus melanotus: LL50(96h): 1900 mg/L
An experiment was performed to assess the
acute aquatic toxicity of the target substance
1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen
peroxide and tert-nonanethiol (CAS 91648-65-6) (McAllister, 1985). The
method followed the OECD Guideline 203, with the exception that the
nominal concentrations were not measured analytically for confirmation.
The preliminary 96 h acute toxicity study was conducted with the Fathead
minnow (Pimephales promelas) at nominal test concentrations of 1,
10 and 100 mg/L. Ten fish per test concentration were used in the
preliminary and the definitive study. In the definitive study test
concentrations of 100, 180, 320, 560 and 1000 mg/L were tested. In
parallel a control, a solvent control and a positive control group were
tested. No mortality occurred at any of the test concentrations. Under
the conditions of the test the LL50 at 96 hours exposure was determined
to be > 1000 mg/L.
Supporting information is given by a 96-h
acute toxicity study. In this experiment golden orfs (Leuciscus idus
melanotus) were exposed to the read-across substance
‘1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen
peroxide and tert-dodecanethiol’ (No CAS, no EC) at nominal
concentrations of 0.1, 0.25, 0.5, 0.75, 1.0, 1.5, 1.75, 2.0, 3.0 and 3.5
g/L under static conditions (Hansonis-Jouleh, 1993). The experiment was
conducted in accordance to OECD 203 in principle. As one deviation from
the guideline the missing control must be mentioned. However, since
nominal concentrations of the test substance up to 0.75 g/L did not
induce lethal effects in fish (i.e. < 10 % as required in the guideline)
and a nominal concentration of 3.5 g/L led to the death of all 10 fish
within the test group, missing controls do not give rise to doubts on
the validity of the test. Another deviation poses the missing analytics.
Although not distinct mentioned in the study report, the test solutions
were prepared as Water Accommodated Fractions (WAFs). Hence, the effect
concentrations are listed as loading rate WAFs, although reported as
concentrations in the study report. During a first test, mortality in
the storage tanks was too high. Thus, the reported test is the
repetition, when the mortality was appropriate. The 96-h LL50 was 1.9
g/L, the LL0 and LL100 values were determined as 0.75 g/L and 3.5 g/L
respectively. Since the test substance was applied as a WAF, the nominal
concentrations are not sufficient to classify the test substance. This
toxicity study was classified as reliable with restrictions and
satisfies mostly the guideline requirements for an acute toxicity test
on L. idus.
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