Registration Dossier
Registration Dossier
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EC number: 273-734-4 | CAS number: 69012-34-6 By-product from open-hearth steelmaking. Consists of oxides of calcium, iron, silicon and vanadium.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Based on available water solubility data, "Slags, steelmaking, vanadium" is rather inert with respect to the dissolution of slag components in water with the exception of slightly soluble vanadium. Aluminum, magnesium, manganese, molybdenum and zinc dissolved at detectable concentrations but these concentrations are neglectable in any physiological meaning. Thus, read-across of skin sensitisation data from soluble tri-, tetra-, and pentavalent vanadium substances is justified.
The studies by Haferkorn (2010a,b,c) are considered key studies on skin sensitisation and are used for classification. Soluble tri-tetra, and pentavalent vanadium substances failed to elicit any skin sensitising response in sensitisation studies according to Magnusson and Kligman (OECD 406). Positive human experience with any vanadium substance have not been reported. Thus, these negative results are read-across to Slags, steelmaking, vanadium. Therefore, no classification and labelling according to directive 67/548/EEC and to regulation (EC) 1272/2008 is required.
Migrated from Short description of key information:
Slags, steelmaking, vanadium is considered inert with the exception of slightly soluble vanadium. Soluble tri-, tetra- and pentavalent vanadium substances did test negative (i.e. not sensitising) in sensitisation studies according to Magnusson and Kligman (OECD 406). A justification for using the Magnusson and Kligman design instead of the LLNA is provided as an attached document below.
Slags, steelmaking, vanadium is considered to have no sensitisation potential.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
Exposure to slags, steelmaking, vanadium has not been reported to induce immune responses in vanadium industry workers, and occupational asthma or reduced lung function have not been diagnosed in vanadium producing facilities. Furthermore, exposure via inhalation is not expected to this transported intermediate under normal operating conditions.
Justification for classification or non-classification
According to the outcome of sensitisation studies with soluble vanadium forms according to Magnusson and Kligman, it can be concluded that "slags, steelmaking , vamadium" is considered to have no sensitisation potential and must not be classified and labelled according to directive 67/548/EEC and to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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